4TW7

The Fk1 domain of FKBP51 in complex with iFit4

Summary for 4TW7

Entry DOI	10.2210/pdb4tw7/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase FKBP5, (1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate (3 entities in total)
Functional Keywords	fk-506 binding domain, hsp90 cochaperone, immunophiline, peptidyl-prolyl isomerase, ligand selectivity, isomerase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q13451
Total number of polymer chains	1
Total formula weight	14827.05
Authors	Gaali, S.,Kirschner, A.,Cuboni, S.,Hartmann, J.,Kozany, C.,Balsevich, G.,Namendorf, C.,Fernandez-Vizarra, P.,Almeida, O.F.X.,Ruehter, G.,Uhr, M.,Schmidt, M.V.,Touma, C.,Bracher, A.,Hausch, F. (deposition date: 2014-06-30, release date: 2014-11-26, Last modification date: 2023-12-20)
Primary citation	Gaali, S.,Kirschner, A.,Cuboni, S.,Hartmann, J.,Kozany, C.,Balsevich, G.,Namendorf, C.,Fernandez-Vizarra, P.,Sippel, C.,Zannas, A.S.,Draenert, R.,Binder, E.B.,Almeida, O.F.,Ruhter, G.,Uhr, M.,Schmidt, M.V.,Touma, C.,Bracher, A.,Hausch, F. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat.Chem.Biol., 11:33-37, 2015 Cited by PubMed: 25436518 DOI: 10.1038/nchembio.1699 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation