6RCY

CRYSTAL STRUCTURE OF FK1 DOMAIN OF FKBP52 IN COMPLEX WITH A BIO-INSPIRED HYBRID FLUORESCENT LIGAND

Summary for 6RCY

Entry DOI	10.2210/pdb6rcy/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase FKBP4, (2~{S})-5-carbamimidamido-2-[[(2~{S})-2-[[(2~{S})-1-[5-(dimethylamino)naphthalen-1-yl]sulfonylpiperidin-2-yl]carbonylamino]-4-phenyl-butanoyl]amino]pentanoic acid (3 entities in total)
Functional Keywords	fkbp52, the n-terminal domain, isomerase, ligand, fluorescence
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	16905.18
Authors	Li de la Sierra-Gallay, I.,Byrne, C. (deposition date: 2019-04-12, release date: 2020-05-13, Last modification date: 2024-01-24)
Primary citation	de la Sierra-Gallay, I.L.,Belnou, M.,Chambraud, B.,Genet, M.,van Tilbeurgh, H.,Aumont-Nicaise, M.,Desmadril, M.,Baulieu, E.E.,Jacquot, Y.,Byrne, C. Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52. J.Med.Chem., 63:10330-10338, 2020 Cited by PubMed: 32866001 DOI: 10.1021/acs.jmedchem.0c00825 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation