7R0L

Structure of the FK1 domain of the FKBP51 G64S variant in complex with SAFit1

Summary for 7R0L

Entry DOI	10.2210/pdb7r0l/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase FKBP5, 2-[3-[(1~{R})-1-[(2~{S})-1-[(2~{S})-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidin-2-yl]carbonyloxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]ethanoic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (5 entities in total)
Functional Keywords	isomerase inhibitor complex, isomerase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	15204.42
Authors	Meyners, C.,Hausch, F. (deposition date: 2022-02-02, release date: 2022-11-16, Last modification date: 2024-01-31)
Primary citation	Lerma Romero, J.A.,Meyners, C.,Christmann, A.,Reinbold, L.M.,Charalampidou, A.,Hausch, F.,Kolmar, H. Binding pocket stabilization by high-throughput screening of yeast display libraries. Front Mol Biosci, 9:1023131-1023131, 2022 Cited by PubMed: 36419931 DOI: 10.3389/fmolb.2022.1023131 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation