4TX0

The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-(2-methoxyethoxy)-3-(2-methoxyethyl)-3,10-diazabicyclo[4.3.1]decan-2-one

Summary for 4TX0

Entry DOI	10.2210/pdb4tx0/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase FKBP5, (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-(2-methoxyethoxy)-3-(2-methoxyethyl)-3,10-diazabicyclo[4.3.1]decan-2-one (3 entities in total)
Functional Keywords	fk-506 binding domain, hsp90 cochaperone, immunophiline, peptidyl-prolyl isomerase, isomerase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q13451
Total number of polymer chains	1
Total formula weight	14521.49
Authors	Bischoff, M.,Sippel, C.,Bracher, A.,Hausch, F. (deposition date: 2014-07-02, release date: 2014-10-15, Last modification date: 2023-12-20)
Primary citation	Bischoff, M.,Sippel, C.,Bracher, A.,Hausch, F. Stereoselective Construction of the 5-Hydroxy Diazabicyclo[4.3.1]decane-2-one Scaffold, a Privileged Motif for FK506-Binding Proteins. Org.Lett., 16:5254-5257, 2014 Cited by PubMed: 25286062 DOI: 10.1021/ol5023195 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.03 Å)

Structure validation