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PDB: 202 件
8EMX
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Phospholipase C beta 3 (PLCb3) in complex with Gbg on lipid nanodiscs
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Falzone, M.E, MacKinnon, R.
登録日2022-09-28
公開日2023-05-24
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
3JZY
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Crystal structure of human Intersectin 2 C2 domain
分子名称: Intersectin 2, UNKNOWN ATOM OR ION
著者Shen, Y, Tempel, W, Tong, Y, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2009-09-24
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Crystal structure of human Intersectin 2 C2 domain
To be Published
5IZ5
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BU of 5iz5 by Molmil
Human GIVD cytosolic phospholipase A2
分子名称: Cytosolic phospholipase A2 delta, SULFATE ION
著者Wang, H, Klein, M.G.
登録日2016-03-24
公開日2016-06-08
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.
J.Mol.Biol., 428, 2016
5IZR
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Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl Fluorophosphonate inhibitor and Terbium Chloride
分子名称: Cytosolic phospholipase A2 delta, TERBIUM(III) ION, methyl (R)-(6Z,9Z,12Z)-octadeca-6,9,12-trien-1-ylphosphonofluoridate
著者Wang, H, Klein, M.G.
登録日2016-03-25
公開日2016-06-08
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.
J.Mol.Biol., 428, 2016
4GNK
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BU of 4gnk by Molmil
Crystal structure of Galphaq in complex with full-length human PLCbeta3
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Lyon, A.M, Tesmer, J.J.G.
登録日2012-08-17
公開日2013-02-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Full-length G alpha (q)-phospholipase C-beta 3 structure reveals interfaces of the C-terminal coiled-coil domain.
Nat.Struct.Mol.Biol., 20, 2013
5KJ7
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BU of 5kj7 by Molmil
Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) - from XFEL diffraction
分子名称: CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ...
著者Lyubimov, A.Y, Uervirojnangkoorn, M, Zhou, Q, Zhao, M, Sauter, N.K, Brewster, A.S, Weis, W.I, Brunger, A.T.
登録日2016-06-17
公開日2016-10-19
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex.
Elife, 5, 2016
5KJ8
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Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) - from synchrotron diffraction
分子名称: CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ...
著者Lyubimov, A.Y, Uervirojnangkoorn, M, Zhou, Q, Zhao, M, Sauter, N.K, Brewster, A.S, Weis, W.I, Brunger, A.T.
登録日2016-06-17
公開日2016-10-19
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex.
Elife, 5, 2016
3NSJ
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BU of 3nsj by Molmil
The X-ray crystal structure of lymphocyte perforin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Law, R.H, Whisstock, J.C, Caradoc-Davies, T.T.
登録日2010-07-01
公開日2010-11-03
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献The structural basis for membrane binding and pore formation by lymphocyte perforin.
Nature, 468, 2010
6KXU
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BON1
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
著者Wang, Q.C, Jiang, M.Q, Isupov, M.N, Sun, L.F, Wu, Y.K.
登録日2019-09-12
公開日2020-09-16
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Crystal Structure of an Arabidopsis Copine providing insights into this protein family
To be published
6KXK
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BON1
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
著者Wang, Q.C, Jiang, M.Q, Isupov, M.N, Sun, L.F, Wu, Y.K.
登録日2019-09-12
公開日2020-09-16
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of an Arabidopsis Copine providing insights into this protein family
To be published
6KZ8
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Crystal structure of plant Phospholipase D alpha complex with phosphatidic acid
分子名称: 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, CALCIUM ION, Phospholipase D alpha 1
著者Li, J.X, Yu, F, Zhang, P.
登録日2019-09-23
公開日2019-11-13
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.291 Å)
主引用文献Crystal structure of plant PLD alpha 1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D.
Cell Res., 30, 2020
6KZ9
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Crystal structure of plant Phospholipase D alpha
分子名称: CALCIUM ION, Phospholipase D alpha 1
著者Li, J.X, Yu, F, Zhang, P.
登録日2019-09-23
公開日2019-10-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Crystal structure of plant PLD alpha 1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D.
Cell Res., 30, 2020
3BXJ
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BU of 3bxj by Molmil
Crystal Structure of the C2-GAP Fragment of synGAP
分子名称: Ras GTPase-activating protein SynGAP
著者Pena, V, Hothorn, M, Eberth, A, Kaschau, N, Parret, A, Gremer, L, Bonneau, F, Ahmadian, M.R, Scheffzek, K.
登録日2008-01-14
公開日2008-03-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction.
Embo Rep., 9, 2008
5CCI
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BU of 5cci by Molmil
Structure of the Mg2+-bound synaptotagmin-1 SNARE complex (short unit cell form)
分子名称: MAGNESIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ...
著者Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Weis, W.I, Brunger, A.T.
登録日2015-07-02
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
5CCH
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BU of 5cch by Molmil
Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (short unit cell form)
分子名称: CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ...
著者Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T.
登録日2015-07-02
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
4QJ4
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BU of 4qj4 by Molmil
Structure of a fragment of human phospholipase C-beta3 delta472-569, bound to IP3 and in complex with Galphaq
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
著者Lyon, A.M, Tesmer, J.J.G.
登録日2014-06-03
公開日2014-10-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
5CCG
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BU of 5ccg by Molmil
Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form)
分子名称: CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ...
著者Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T.
登録日2015-07-02
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
4P42
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Extended-Synaptotagmin 2, SMP - C2A - C2B Domains
分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOX Y}-ETHOXY)-ETHANOL, Extended synaptotagmin-2
著者Schauder, C.M, Wu, X, Reinisch, K.M.
登録日2014-03-10
公開日2014-05-14
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.
Nature, 510, 2014
2ISD
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BU of 2isd by Molmil
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT
分子名称: ACETATE ION, PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ISOZYME DELTA1
著者Essen, L.-O, Perisic, O, Williams, R.L.
登録日1997-03-31
公開日1997-07-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.
Nature, 380, 1996
2K8M
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S100A13-C2A binary complex structure
分子名称: Protein S100-A13, Putative uncharacterized protein
著者Mohan, S.K, Rani, S.G, Kumar, S.M, Yu, C.
登録日2008-09-14
公開日2009-03-17
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献S100A13-C2A binary complex structure-a key component in the acidic fibroblast growth factor for the non-classical pathway.
Biochem.Biophys.Res.Commun., 380, 2009
4QJ3
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Structure of a fragment of human phospholipase C-beta3 delta472-559, in complex with Galphaq
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Lyon, A.M, Tesmer, J.J.G.
登録日2014-06-03
公開日2014-10-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
4QJ5
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Structure of a fragment of human phospholipase C-beta3 delta472-581, bound to IP3 and in complex with Galphaq
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
著者Lyon, A.M, Tesmer, J.J.G.
登録日2014-06-03
公開日2014-10-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.41 Å)
主引用文献Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
2N1T
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Dynamic binding mode of a synaptotagmin-1-SNARE complex in solution
分子名称: Synaptosomal-associated protein 25, Synaptotagmin-1, Syntaxin-1A, ...
著者Brewer, K, Bacaj, T, Cavalli, A, Camilloni, C, Swarbrick, J, Liu, J, Zhou, A, Zhou, P, Barlow, N, Xu, J, Seven, A, Prinslow, E, Voleti, R, Haussinger, D, Bonvin, A, Tomchick, D, Vendruscolo, M, Graham, B, Sudhof, T, Rizo, J.
登録日2015-04-21
公開日2015-06-03
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution.
Nat.Struct.Mol.Biol., 22, 2015
1QAT
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1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA COMPLEX WITH SAMARIUM (III) CHLORIDE
分子名称: PHOSPHOLIPASE C DELTA-1, SAMARIUM (III) ION
著者Grobler, J.A, Hurley, J.H.
登録日1996-08-02
公開日1997-02-12
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献C2 domain conformational changes in phospholipase C-delta 1.
Nat.Struct.Biol., 3, 1996
1QAS
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1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1
分子名称: PHOSPHOLIPASE C DELTA-1
著者Grobler, J.A, Hurley, J.H.
登録日1996-08-02
公開日1997-02-12
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献C2 domain conformational changes in phospholipase C-delta 1.
Nat.Struct.Biol., 3, 1996

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