4P42

Extended-Synaptotagmin 2, SMP - C2A - C2B Domains

Summary for 4P42

Entry DOI	10.2210/pdb4p42/pdb
Descriptor	Extended synaptotagmin-2, 2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOX Y}-ETHOXY)-ETHANOL, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... (4 entities in total)
Functional Keywords	endocytosis, signal transduction, membrane contact site, lipid binding, lipid transport
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Peripheral membrane protein: A0FGR8
Total number of polymer chains	2
Total formula weight	111114.22
Authors	Schauder, C.M.,Wu, X.,Reinisch, K.M. (deposition date: 2014-03-10, release date: 2014-05-14, Last modification date: 2023-12-27)
Primary citation	Schauder, C.M.,Wu, X.,Saheki, Y.,Narayanaswamy, P.,Torta, F.,Wenk, M.R.,De Camilli, P.,Reinisch, K.M. Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Nature, 510:552-555, 2014 Cited by PubMed: 24847877 DOI: 10.1038/nature13269 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.44 Å)

Structure validation