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PDB: 730 件
3F99
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W354F Yersinia enterocolitica PTPase apo form
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase yopH
著者Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C.
登録日2008-11-13
公開日2009-01-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.
J.Am.Chem.Soc., 131, 2009
1G7G
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HUMAN PTP1B CATALYTIC DOMAIN COMPLEXES WITH PNU179326
分子名称: 2-(CARBOXYMETHOXY)-5-[(2S)-2-({(2S)-2-[(3-CARBOXYPROPANOYL)AMINO] -3-PHENYLPROPANOYL}AMINO)-3-OXO-3-(PENTYLAMINO)PROPYL]BENZOIC ACID, PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1
著者Bleasdale, J.E, Ogg, D, Larsen, S.D.
登録日2000-11-10
公開日2001-06-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
Biochemistry, 40, 2001
1KAV
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Human Tyrosine Phosphatase 1B Complexed with an Inhibitor
分子名称: PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, [(4-{4-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-BUTYL}-PHENYL)-DIFLUORO-METHYL]-PHOSPHONIC ACID
著者Jia, Z, Ye, Q, Dinaut, A.N, Wang, Q, Waddleton, D, Payette, P, Ramachandran, C, Kennedy, B, Hum, G, Taylor, S.D.
登録日2001-11-03
公開日2002-06-19
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.
J.Med.Chem., 44, 2001
1G1G
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A MONO-PHOSPHORYLATED PEPTIDE (ETDY(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
分子名称: MONO-PHOSPHORYLATED PEPTIDE FROM THE INSULIN RECEPTOR KINASE, PROTEIN TYROSINE PHOSPHATASE 1B
著者Salmeen, A, Andersen, J.N, Myers, M.P, Tonks, N.K, Barford, D.
登録日2000-10-11
公開日2001-01-17
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
8DU7
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Room-temperature serial synchrotron crystallography (SSX) structure of apo PTP1B
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
著者Ebrahim, A, Sharma, S, Keedy, D.A.
登録日2022-07-27
公開日2022-08-17
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B.
Acta Crystallogr.,Sect.F, 79, 2023
3D42
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Crystal structure of HePTP in complex with a monophosphorylated Erk2 peptide
分子名称: D(-)-TARTARIC ACID, GLYCEROL, Mitogen-activated protein kinase 1 peptide, ...
著者Critton, D.A, Tortajada, A, Page, R.
登録日2008-05-13
公開日2009-03-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Structural basis of substrate recognition by hematopoietic tyrosine phosphatase.
Biochemistry, 47, 2008
1G1F
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A TRI-PHOSPHORYLATED PEPTIDE (RDI(PTR)ETD(PTR)(PTR)RK) FROM THE INSULIN RECEPTOR KINASE
分子名称: PROTEIN TYROSINE PHOSPHATASE 1B, TRI-PHOSPHORYLATED PEPTIDE FROM THE INSULIN RECEPTOR KINASE
著者Salmeen, A, Andersen, J.N, Myers, M.P, Tonks, N.K, Barford, D.
登録日2000-10-11
公開日2001-01-17
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1GFY
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RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA
分子名称: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
著者Iversen, L.F.
登録日2000-06-26
公開日2000-07-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha.
J.Biol.Chem., 275, 2000
3F9A
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W354F Yersinia enterocolitica PTPase complexed with tungstate
分子名称: TUNGSTATE(VI)ION, Tyrosine-protein phosphatase yopH
著者Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C.
登録日2008-11-13
公開日2009-01-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.
J.Am.Chem.Soc., 131, 2009
3F9B
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W354F Yersinia enterocolitica PTPase complexed with divanadate
分子名称: Divanadate ion, GLYCEROL, Tyrosine-protein phosphatase yopH, ...
著者Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C.
登録日2008-11-13
公開日2009-01-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.
J.Am.Chem.Soc., 131, 2009
1KAK
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BU of 1kak by Molmil
Human Tyrosine Phosphatase 1B Complexed with an Inhibitor
分子名称: PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, {[7-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALEN-2-YL]-DIFLUORO-METHYL}-PHOSPHONIC ACID
著者Jia, Z, Ye, Q, Dinaut, A.N, Wang, Q, Waddleton, D, Payette, P, Ramachandran, C, Kennedy, B, Hum, G, Taylor, S.D.
登録日2001-11-02
公開日2002-06-19
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.
J.Med.Chem., 44, 2001
1GWZ
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1
分子名称: SHP-1
著者Yang, J, Liang, X, Niu, T, Meng, W, Zhao, Z, Zhou, G.W.
登録日1998-08-22
公開日1999-08-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 273, 1998
3D44
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Crystal structure of HePTP in complex with a dually phosphorylated Erk2 peptide mimetic
分子名称: CHLORIDE ION, GLYCEROL, Mitogen-activated protein kinase 1 peptide, ...
著者Critton, D.A, Tortajada, A, Page, R.
登録日2008-05-13
公開日2009-03-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis of substrate recognition by hematopoietic tyrosine phosphatase.
Biochemistry, 47, 2008
8EYB
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Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with JAK2 activation loop phosphopeptide
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein kinase JAK2 activation loop phosphopeptide, Tyrosine-protein phosphatase non-receptor type 1
著者Morris, R, Kershaw, N.J, Babon, J.J.
登録日2022-10-26
公開日2023-07-05
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.349 Å)
主引用文献Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXJ
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BU of 8exj by Molmil
Crystal structure of PTP1B D181A/Q262A phosphatase domain in complex with a JAK1 activation loop phosphopeptide
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, Tyrosine-protein kinase JAK1 activation loop peptide, ...
著者Morris, R, Kershaw, N.J, Babon, J.J.
登録日2022-10-25
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXI
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BU of 8exi by Molmil
Crystal structure of apo PTP1B D181A/Q262A phosphatase domain
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Tyrosine-protein phosphatase non-receptor type 1
著者Morris, R, Kershaw, N.J, Babon, J.J.
登録日2022-10-25
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXM
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Crystal structure of PTP1B D181A/Q262A phosphatase domain with a JAK3 activation loop phosphopeptide
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, Tyrosine-protein kinase JAK3 activation loop peptide, ...
著者Morris, R, Kershaw, N.J, Babon, J.J.
登録日2022-10-25
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.349 Å)
主引用文献Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXK
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Crystal structure of PTP1B D181A/Q262A phosphatase domain with JAK2 activation loop phosphopeptide
分子名称: PHOSPHATE ION, Tyrosine-protein kinase JAK2 activation loop peptide, Tyrosine-protein phosphatase non-receptor type 1
著者Morris, R, Kershaw, N.J, Babon, J.J.
登録日2022-10-25
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.096 Å)
主引用文献Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXN
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Crystal structure of PTP1B D181A/Q262A phosphatase domain with TYK2 activation loop phosphopeptide
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Non-receptor tyrosine-protein kinase TYK2 activation loop peptide, PHOSPHATE ION, ...
著者Morris, R, Kershaw, N.J, Babon, J.J.
登録日2022-10-25
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.151 Å)
主引用文献Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EYA
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BU of 8eya by Molmil
Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with a JAK2 activation loop phosphopeptide
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Morris, R, Kershaw, N.J, Babon, J.J.
登録日2022-10-26
公開日2023-07-05
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8F88
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Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with monophosphorylated JAK2 activation loop phosphopeptide
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein kinase JAK2, Tyrosine-protein phosphatase non-receptor type 1
著者Morris, R, Kershaw, N.J, Babon, J.J.
登録日2022-11-21
公開日2023-07-05
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
1L8K
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T Cell Protein-Tyrosine Phosphatase Structure
分子名称: T-cell protein-tyrosine phosphatase
著者Iversen, L.F.
登録日2002-03-21
公開日2002-05-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Structure determination of T cell protein-tyrosine phosphatase.
J.Biol.Chem., 277, 2002
1L8G
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Crystal structure of PTP1B complexed with 7-(1,1-Dioxo-1H-benzo[d]isothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid
分子名称: 7-(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3-YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1
著者Iversen, L.F, Andersen, H.S, Moller, K.B, Olsen, O.H, Peters, G.H, Branner, S, Mortensen, S.B, Hansen, T.K, Lau, J, Ge, Y, Holsworth, D.D, Newman, M.J, Moller, N.P.H.
登録日2002-03-20
公開日2002-05-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.
Biochemistry, 40, 2001
1LAR
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CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAINS OF RPTP LAR
分子名称: PROTEIN (LAR)
著者Nam, H.-J, Poy, F, Krueger, N, Saito, H, Frederick, C.A.
登録日1999-04-20
公開日2000-04-25
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the tandem phosphatase domains of RPTP LAR.
Cell(Cambridge,Mass.), 97, 1999
3CWE
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PTP1B in complex with a phosphonic acid inhibitor
分子名称: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1, [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid
著者Scapin, G, Han, Y, Kennedy, B.P.
登録日2008-04-21
公開日2008-06-10
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor
Bioorg.Med.Chem.Lett., 18, 2008

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