1KAK
Human Tyrosine Phosphatase 1B Complexed with an Inhibitor
Summary for 1KAK
Entry DOI | 10.2210/pdb1kak/pdb |
Related | 1KAV |
Descriptor | PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, {[7-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALEN-2-YL]-DIFLUORO-METHYL}-PHOSPHONIC ACID (3 entities in total) |
Functional Keywords | protein-inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35108.71 |
Authors | Jia, Z.,Ye, Q.,Dinaut, A.N.,Wang, Q.,Waddleton, D.,Payette, P.,Ramachandran, C.,Kennedy, B.,Hum, G.,Taylor, S.D. (deposition date: 2001-11-02, release date: 2002-06-19, Last modification date: 2023-08-16) |
Primary citation | Jia, Z.,Ye, Q.,Dinaut, A.N.,Wang, Q.,Waddleton, D.,Payette, P.,Ramachandran, C.,Kennedy, B.,Hum, G.,Taylor, S.D. Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics. J.Med.Chem., 44:4584-4594, 2001 Cited by PubMed: 11741477DOI: 10.1021/jm010266w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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