1KAV

Human Tyrosine Phosphatase 1B Complexed with an Inhibitor

Summary for 1KAV

Related1KAK
DescriptorPROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, [(4-{4-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-BUTYL}-PHENYL)-DIFLUORO-METHYL]-PHOSPHONIC ACID (3 entities in total)
Functional Keywordsprotein-inhibitor complex, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side  P18031
Total number of polymer chains1
Total molecular weight35190.85
Authors
Jia, Z.,Ye, Q.,Dinaut, A.N.,Wang, Q.,Waddleton, D.,Payette, P.,Ramachandran, C.,Kennedy, B.,Hum, G.,Taylor, S.D. (deposition date: 2001-11-03, release date: 2002-06-19, Last modification date: 2011-07-13)
Primary citation
Jia, Z.,Ye, Q.,Dinaut, A.N.,Wang, Q.,Waddleton, D.,Payette, P.,Ramachandran, C.,Kennedy, B.,Hum, G.,Taylor, S.D.
Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.
J.Med.Chem., 44:4584-4594, 2001
PubMed: 11741477 (PDB entries with the same primary citation)
DOI: 10.1021/jm010266w
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.35 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.241101.0%4.1%8.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-07-29