6PT0
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![BU of 6pt0 by Molmil](/molmil-images/mine/6pt0) | Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2 | 分子名称: | CHOLESTEROL, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, T.H, Xing, C, Zhuang, Y, Feng, Z, Zhou, X.E, Chen, M, Wang, L, Meng, X, Xue, Y, Wang, J, Liu, H, McGuire, T, Zhao, G, Melcher, K, Zhang, C, Xu, H.E, Xie, X.Q. | 登録日 | 2019-07-14 | 公開日 | 2020-02-12 | 最終更新日 | 2020-03-04 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM Structure of the Human Cannabinoid Receptor CB2-GiSignaling Complex. Cell, 180, 2020
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3P0G
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![BU of 3p0g by Molmil](/molmil-images/mine/3p0g) | Structure of a nanobody-stabilized active state of the beta2 adrenoceptor | 分子名称: | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Beta-2 adrenergic receptor, Lysozyme, ... | 著者 | Rasmussen, S.G.F, Choi, H.-J, Fung, J.J, Pardon, E, Casarosa, P, Chae, P.S, DeVree, B.T, Rosenbaum, D.M, Thian, F.S, Kobilka, T.S, Schnapp, A, Konetzki, I, Sunahara, R.K, Gellman, S.H, Pautsch, A, Steyaert, J, Weis, W.I, Kobilka, B.K. | 登録日 | 2010-09-28 | 公開日 | 2011-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure of a nanobody-stabilized active state of the b2 adrenoceptor Nature, 469, 2011
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6QNO
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![BU of 6qno by Molmil](/molmil-images/mine/6qno) | Rhodopsin-Gi protein complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab antibody fragment heavy chain, Fab antibody fragment light chain, ... | 著者 | Tsai, C.-J, Marino, J, Adaixo, R.J, Pamula, F, Muehle, J, Maeda, S, Flock, T, Taylor, N.M.I, Mohammed, I, Matile, H, Dawson, R.J.P, Deupi, X, Stahlberg, H, Schertler, G.F.X. | 登録日 | 2019-02-11 | 公開日 | 2019-07-10 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.38 Å) | 主引用文献 | Cryo-EM structure of the rhodopsin-G alpha i-beta gamma complex reveals binding of the rhodopsin C-terminal tail to the G beta subunit. Elife, 8, 2019
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6NWE
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6OBA
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![BU of 6oba by Molmil](/molmil-images/mine/6oba) | The beta2 adrenergic receptor bound to a negative allosteric modulator | 分子名称: | (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, 6-bromo-N~2~-phenylquinazoline-2,4-diamine, Beta-2 adrenergic receptor,Lysozyme,Beta-2 adrenergic receptor, ... | 著者 | Liu, X, Stobel, A, Kaindl, J, Dengler, D, ClarK, M, Mahoney, J, Korczynska, M, Matt, R.A, Hubner, H, Xu, X, Stanek, M, Hirata, K, Shoichet, B, Sunahara, R, Gmeiner, R, Kobilka, B.K. | 登録日 | 2019-03-20 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | An allosteric modulator binds to a conformational hub in the beta2adrenergic receptor. Nat.Chem.Biol., 16, 2020
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6OIJ
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![BU of 6oij by Molmil](/molmil-images/mine/6oij) | Muscarinic acetylcholine receptor 1-G11 protein complex | 分子名称: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Maeda, S, Qianhui, Q, Skiniotis, G, Kobilka, B. | 登録日 | 2019-04-09 | 公開日 | 2019-05-08 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science, 364, 2019
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6OSA
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![BU of 6osa by Molmil](/molmil-images/mine/6osa) | human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation (NC state) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. | 登録日 | 2019-05-01 | 公開日 | 2019-07-10 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Conformational transitions of a neurotensin receptor 1-Gi1complex. Nature, 572, 2019
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6OYA
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![BU of 6oya by Molmil](/molmil-images/mine/6oya) | Structure of the Rhodopsin-Transducin-Nanobody Complex | 分子名称: | Camelid antibody VHH fragment, Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Gao, Y, Hu, H, Ramachandran, S, Erickson, J.W, Cerione, R.A, Skiniotis, G. | 登録日 | 2019-05-14 | 公開日 | 2019-07-24 | 最終更新日 | 2019-12-04 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation. Mol.Cell, 75, 2019
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6RZ8
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![BU of 6rz8 by Molmil](/molmil-images/mine/6rz8) | Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2080365 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2~{S})-8-[[4-[4-[2,3-bis(fluoranyl)phenoxy]butoxy]-2-fluoranyl-phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-but yl)-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid, Cysteinyl leukotriene receptor 2,Soluble cytochrome b562,Cysteinyl leukotriene receptor 2, ... | 著者 | Gusach, A, Luginina, A, Marin, E, Brouillette, R.L, Besserer-Offroy, E, Longpre, J.M, Ishchenko, A, Popov, P, Fujimoto, T, Maruyama, T, Stauch, B, Ergasheva, M, Romanovskaya, D, Stepko, A, Kovalev, K, Shevtsov, M, Gordeliy, V, Han, G.W, Sarret, P, Katritch, V, Borshchevskiy, V, Mishin, A, Cherezov, V. | 登録日 | 2019-06-12 | 公開日 | 2019-12-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nat Commun, 10, 2019
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3PQR
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![BU of 3pqr by Molmil](/molmil-images/mine/3pqr) | Crystal structure of Metarhodopsin II in complex with a C-terminal peptide derived from the Galpha subunit of transducin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, ... | 著者 | Choe, H.-W, Kim, Y.J, Park, J.H, Morizumi, T, Pai, E.F, Krauss, N, Hofmann, K.P, Scheerer, P, Ernst, O.P. | 登録日 | 2010-11-26 | 公開日 | 2011-03-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Crystal structure of metarhodopsin II. Nature, 471, 2011
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6RZ5
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![BU of 6rz5 by Molmil](/molmil-images/mine/6rz5) | XFEL crystal structure of the human cysteinyl leukotriene receptor 1 in complex with zafirlukast | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1, OLEIC ACID, ... | 著者 | Luginina, A, Gusach, A, Marin, E, Mishin, A, Brouillette, R, Popov, P, Shiryaeva, A, Besserer-Offroy, E, Longpre, J.M, Lyapina, E, Ishchenko, A, Patel, N, Polovinkin, V, Safronova, N, Bogorodskiy, A, Edelweiss, E, Liu, W, Batyuk, A, Gordeliy, V, Han, G.W, Sarret, P, Katritch, V, Borshchevskiy, V, Cherezov, V. | 登録日 | 2019-06-12 | 公開日 | 2019-10-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs. Sci Adv, 5, 2019
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6S0Q
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![BU of 6s0q by Molmil](/molmil-images/mine/6s0q) | Structure of the A2A adenosine receptor determined at SwissFEL using native-SAD at 4.57 keV from 50,000 diffraction patterns | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... | 著者 | Nass, K, Cheng, R, Vera, L, Mozzanica, A, Redford, S, Ozerov, D, Basu, S, James, D, Knopp, G, Cirelli, C, Martiel, I, Casadei, C, Weinert, T, Nogly, P, Skopintsev, P, Usov, I, Leonarski, F, Geng, T, Rappas, M, Dore, A.S, Cooke, R, Nasrollahi Shirazi, S, Dworkowski, F, Sharpe, M, Olieric, N, Steinmetz, M.O, Schertler, G, Abela, R, Patthey, L, Schmitt, B, Hennig, M, Standfuss, J, Wang, M, Milne, J.C. | 登録日 | 2019-06-18 | 公開日 | 2020-07-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Advances in long-wavelength native phasing at X-ray free-electron lasers. Iucrj, 7, 2020
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3QAK
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![BU of 3qak by Molmil](/molmil-images/mine/3qak) | Agonist bound structure of the human adenosine A2a receptor | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, Adenosine receptor A2a,lysozyme chimera | 著者 | Xu, F, Wu, H, Katritch, V, Han, G.W, Cherezov, V, Stevens, R, GPCR Network (GPCR) | 登録日 | 2011-01-11 | 公開日 | 2011-03-09 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Structure of an agonist-bound human A2A adenosine receptor. Science, 332, 2011
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6OMM
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![BU of 6omm by Molmil](/molmil-images/mine/6omm) | Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhuang, Y, Liu, H, de Waal, P.W, Zhou, X.E, Wang, L, Meng, X, Zhao, G, Kang, Y, Melcher, K, Xu, H.E, Zhang, C. | 登録日 | 2019-04-19 | 公開日 | 2020-02-26 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Structure of formylpeptide receptor 2-Gicomplex reveals insights into ligand recognition and signaling. Nat Commun, 11, 2020
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6OS0
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![BU of 6os0 by Molmil](/molmil-images/mine/6os0) | Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to angiotensin II | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensinogen, CHLORIDE ION, ... | 著者 | Wingler, L.M, Staus, D.P, Skiba, M.A, McMahon, C, Kleinhenz, A.L.W, Lefkowitz, R.J, Kruse, A.C. | 登録日 | 2019-05-01 | 公開日 | 2020-02-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science, 367, 2020
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6OIK
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![BU of 6oik by Molmil](/molmil-images/mine/6oik) | Muscarinic acetylcholine receptor 2-Go complex | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment, ... | 著者 | Maeda, S, Qianhui, Q, Skiniotis, G, Kobilka, B. | 登録日 | 2019-04-09 | 公開日 | 2019-05-08 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science, 364, 2019
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6PEL
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3PBL
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![BU of 3pbl by Molmil](/molmil-images/mine/3pbl) | Structure of the human dopamine D3 receptor in complex with eticlopride | 分子名称: | 3-chloro-5-ethyl-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxy-2-methoxybenzamide, D(3) dopamine receptor, Lysozyme chimera, ... | 著者 | Chien, E.Y.T, Liu, W, Han, G.W, Katritch, V, Zhao, Q, Cherezov, V, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR) | 登録日 | 2010-10-20 | 公開日 | 2010-11-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Structure of the human dopamine d3 receptor in complex with a d2/d3 selective antagonist. Science, 330, 2010
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6PWC
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![BU of 6pwc by Molmil](/molmil-images/mine/6pwc) | A complex structure of arrestin-2 bound to neurotensin receptor 1 | 分子名称: | Beta-arrestin-1, Fab30 heavy chain, Fab30 light chain, ... | 著者 | Yin, W, Li, Z, Jin, M, Yin, Y.-L, de Waal, P.W, Pal, K, Gao, X, He, Y, Gao, J, Wang, X, Zhang, Y, Zhou, H, Melcher, K, Jiang, Y, Cong, Y, Zhou, X.E, Yu, X, Xu, H.E. | 登録日 | 2019-07-22 | 公開日 | 2019-12-04 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | A complex structure of arrestin-2 bound to a G protein-coupled receptor. Cell Res., 29, 2019
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3OE0
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![BU of 3oe0 by Molmil](/molmil-images/mine/3oe0) | Crystal structure of the CXCR4 chemokine receptor in complex with a cyclic peptide antagonist CVX15 | 分子名称: | C-X-C chemokine receptor type 4, Lysozyme Chimera, Polyphemusin analog, ... | 著者 | Wu, B, Mol, C.D, Han, G.W, Katritch, V, Chien, E.Y.T, Liu, W, Cherezov, V, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR) | 登録日 | 2010-08-12 | 公開日 | 2010-10-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science, 330, 2010
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6PS7
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![BU of 6ps7 by Molmil](/molmil-images/mine/6ps7) | XFEL A2aR structure by ligand exchange from LUF5843 to ZM241385. | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... | 著者 | Ishchenko, A, Stauch, B, Han, G.W, Batyuk, A, Shiriaeva, A, Li, C, Zatsepin, N.A, Weierstall, U, Liu, W, Nango, E, Nakane, T, Tanaka, R, Tono, K, Joti, Y, Iwata, S, Moraes, I, Gati, C, Cherezov, C. | 登録日 | 2019-07-12 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Toward G protein-coupled receptor structure-based drug design using X-ray lasers. Iucrj, 6, 2019
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6OS1
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![BU of 6os1 by Molmil](/molmil-images/mine/6os1) | Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV023 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Nanobody Nb.AT110i1_le, ... | 著者 | Wingler, L.M, Staus, D.P, Skiba, M.A, McMahon, C, Kleinhenz, A.L.W, Lefkowitz, R.J, Kruse, A.C. | 登録日 | 2019-05-01 | 公開日 | 2020-02-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.794 Å) | 主引用文献 | Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science, 367, 2020
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6OS2
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![BU of 6os2 by Molmil](/molmil-images/mine/6os2) | Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV026 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Wingler, L.M, Staus, D.P, Skiba, M.A, McMahon, C, Kleinhenz, A.L.W, Lefkowitz, R.J, Kruse, A.C. | 登録日 | 2019-05-01 | 公開日 | 2020-02-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science, 367, 2020
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6OS9
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![BU of 6os9 by Molmil](/molmil-images/mine/6os9) | human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. | 登録日 | 2019-05-01 | 公開日 | 2019-07-10 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Conformational transitions of a neurotensin receptor 1-Gi1complex. Nature, 572, 2019
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6PGS
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![BU of 6pgs by Molmil](/molmil-images/mine/6pgs) | |