6PS7
XFEL A2aR structure by ligand exchange from LUF5843 to ZM241385.
Summary for 6PS7
Entry DOI | 10.2210/pdb6ps7/pdb |
Descriptor | Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (8 entities in total) |
Functional Keywords | gpcr, complex-lcp method, sbdd, drug design, xfel, lcp-sfx, ligand exchange, luf5843, zm241385, a2aar, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 58144.17 |
Authors | Ishchenko, A.,Stauch, B.,Han, G.W.,Batyuk, A.,Shiriaeva, A.,Li, C.,Zatsepin, N.A.,Weierstall, U.,Liu, W.,Nango, E.,Nakane, T.,Tanaka, R.,Tono, K.,Joti, Y.,Iwata, S.,Moraes, I.,Gati, C.,Cherezov, C. (deposition date: 2019-07-12, release date: 2019-11-13, Last modification date: 2023-10-11) |
Primary citation | Ishchenko, A.,Stauch, B.,Han, G.W.,Batyuk, A.,Shiriaeva, A.,Li, C.,Zatsepin, N.,Weierstall, U.,Liu, W.,Nango, E.,Nakane, T.,Tanaka, R.,Tono, K.,Joti, Y.,Iwata, S.,Moraes, I.,Gati, C.,Cherezov, V. Toward G protein-coupled receptor structure-based drug design using X-ray lasers. Iucrj, 6:1106-1119, 2019 Cited by PubMed: 31709066DOI: 10.1107/S2052252519013137 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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