6RZ8

Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2080365

Summary for 6RZ8

• Entry DOI: 10.2210/pdb6rz8/pdb
• Descriptor: Cysteinyl leukotriene receptor 2,Soluble cytochrome b562,Cysteinyl leukotriene receptor 2, (2~{S})-8-[[4-[4-[2,3-bis(fluoranyl)phenoxy]butoxy]-2-fluoranyl-phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-but yl)-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (5 entities in total)
• Functional Keywords: gpcr, lcp, membrane protein, cysteinyl leukotriene, cyslt2, cysltr2, cyslt2r, asthma, bril, cysteinyl leukotriene receptor 2
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 51011.30

Authors

Gusach, A.,Luginina, A.,Marin, E.,Brouillette, R.L.,Besserer-Offroy, E.,Longpre, J.M.,Ishchenko, A.,Popov, P.,Fujimoto, T.,Maruyama, T.,Stauch, B.,Ergasheva, M.,Romanovskaya, D.,Stepko, A.,Kovalev, K.,Shevtsov, M.,Gordeliy, V.,Han, G.W.,Sarret, P.,Katritch, V.,Borshchevskiy, V.,Mishin, A.,Cherezov, V. (deposition date: 2019-06-12, release date: 2019-12-11, Last modification date: 2024-01-24)

• Primary citation: Gusach, A.,Luginina, A.,Marin, E.,Brouillette, R.L.,Besserer-Offroy, E.,Longpre, J.M.,Ishchenko, A.,Popov, P.,Patel, N.,Fujimoto, T.,Maruyama, T.,Stauch, B.,Ergasheva, M.,Romanovskaia, D.,Stepko, A.,Kovalev, K.,Shevtsov, M.,Gordeliy, V.,Han, G.W.,Katritch, V.,Borshchevskiy, V.,Sarret, P.,Mishin, A.,Cherezov, V.; Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.; Nat Commun, 10:5573-5573, 2019; PubMed: 31811124; DOI: 10.1038/s41467-019-13348-2

Experimental method

X-RAY DIFFRACTION (2.7 Å)