6RZ8

Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2080365

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cysteinyl leukotriene receptor 2,Soluble cytochrome b562,Cysteinyl leukotriene receptor 2	polymer	405	45996.0	1	UniProt (Q9NS75) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB	Homo sapiens (Human)	CysLTR2,G-protein coupled receptor GPCR21,hGPCR21,G-protein coupled receptor HG57,HPN321,Cytochrome b-562,CysLTR2,G-protein coupled receptor GPCR21,hGPCR21,G-protein coupled receptor HG57,HPN321
2	A	(2~{S})-8-[[4-[4-[2,3-bis(fluoranyl)phenoxy]butoxy]-2-fluoranyl-phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-but yl)-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid	non-polymer		602.6	1	Chemie (KNZ)
3	A	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	10	Chemie (OLC)
4	A	OLEIC ACID	non-polymer		282.5	3	Chemie (OLA)
5		water	water		18.0	17	Chemie (HOH)

Sequence modifications

A: 17 - 232 (UniProt: Q9NS75)

PDB	External Database	Details
Val 51	Trp 51	engineered mutation
Asn 84	Asp 84	engineered mutation
Tyr 137	Phe 137	engineered mutation

A: 1001 - 1106 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 1007	Met 29	engineered mutation
Ile 1102	His 124	engineered mutation
Leu 1106	Arg 128	engineered mutation

A: 240 - 322 (UniProt: Q9NS75)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	45996.0
Non-Polymers*	Number of molecules	14
	Total formula weight	5015.3
All*	Total formula weight	51011.3

*Water molecules are not included.