6RZ8
Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2080365
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cysteinyl leukotriene receptor 2,Soluble cytochrome b562,Cysteinyl leukotriene receptor 2 | polymer | 405 | 45996.0 | 1 | UniProt (Q9NS75) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens (Human) | CysLTR2,G-protein coupled receptor GPCR21,hGPCR21,G-protein coupled receptor HG57,HPN321,Cytochrome b-562,CysLTR2,G-protein coupled receptor GPCR21,hGPCR21,G-protein coupled receptor HG57,HPN321 |
| 2 | B (A) | (2~{S})-8-[[4-[4-[2,3-bis(fluoranyl)phenoxy]butoxy]-2-fluoranyl-phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-but yl)-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid | non-polymer | 602.6 | 1 | Chemie (KNZ) | |||
| 3 | C, D, E, F, G... (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 10 | Chemie (OLC) | |||
| 4 | M, N, O (A) | OLEIC ACID | non-polymer | 282.5 | 3 | Chemie (OLA) | |||
| 5 | P (A) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A: 17 - 232 (UniProt: Q9NS75)
A: 1001 - 1106 (UniProt: P0ABE7)
A: 240 - 322 (UniProt: Q9NS75)
| PDB | External Database | Details |
|---|---|---|
| Val 51 | Trp 51 | engineered mutation |
| Asn 84 | Asp 84 | engineered mutation |
| Tyr 137 | Phe 137 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45996.0 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 5015.3 | |
| All* | Total formula weight | 51011.3 |
