7VIF
| Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P | 分子名称: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | 登録日 | 2021-09-26 | 公開日 | 2022-09-28 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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8YW5
| Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex | 分子名称: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W. | 登録日 | 2024-03-29 | 公開日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10, 2024
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8JLQ
| Fenoldopam-bound hTAAR1-Gs protein complex | 分子名称: | (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | 登録日 | 2023-06-02 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature, 624, 2023
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8JGB
| CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2 | 分子名称: | Conorfamide-Tx2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. | 登録日 | 2023-05-20 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
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8GUR
| Cryo-EM structure of CP-CB2-G protein complex | 分子名称: | 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H. | 登録日 | 2022-09-13 | 公開日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
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7VUY
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8IHB
| Cryo-EM structure of HCA2-Gi complex with GSK256073 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | 登録日 | 2023-02-22 | 公開日 | 2023-09-13 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
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7XAT
| Structure of somatostatin receptor 2 bound with SST14. | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L. | 登録日 | 2022-03-19 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discov, 8, 2022
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8FYE
| 4-F, 5-MeO-PyrT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | 分子名称: | 4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | 登録日 | 2023-01-26 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
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8JIP
| Cryo-EM structure of the GLP-1R/GCGR dual agonist MEDI0382-bound human GLP-1R-Gs complex | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yang, L, Zhou, Q.T, Dai, A.T, Zhao, F.H, Chang, R.L, Ying, T.L, Wu, B.L, Yang, D.H, Wang, M.W, Cong, Z.T. | 登録日 | 2023-05-27 | 公開日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural analysis of the dual agonism at GLP-1R and GCGR. Proc.Natl.Acad.Sci.USA, 120, 2023
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8IOC
| Cryo-EM structure of the gamma-MSH-bound human melanocortin receptor 3 (MC3R)-Gs complex | 分子名称: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, ... | 著者 | Feng, W.B, Zhou, Q.T, Chen, X.Y, Dai, A.T, Cai, X.Q, Liu, X, Zhao, F.H, Chen, Y, Ye, C.Y, Xu, Y.N, Cong, Z.T, Li, H, Lin, S. | 登録日 | 2023-03-10 | 公開日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors. Cell Discov, 9, 2023
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8IA8
| Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide | 分子名称: | ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG, C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liao, Q, Chen, G, Du, Y, Ye, R.D. | 登録日 | 2023-02-08 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide To Be Published
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7PIV
| Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution. | 分子名称: | CALCIUM ION, Camelid antibody VHH fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P. | 登録日 | 2021-08-23 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide. Cell Res., 31, 2021
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7EO4
| Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to BAF312 | 分子名称: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Y, Xu, Z, Ikuta, T, Inoue, A. | 登録日 | 2021-04-21 | 公開日 | 2022-01-05 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18, 2022
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7VIE
| Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with S1P | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | 登録日 | 2021-09-26 | 公開日 | 2022-09-28 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7P02
| Human Neurokinin 1 receptor (NK1R) substance P Gs complex | 分子名称: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. | 登録日 | 2021-06-29 | 公開日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
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7WCN
| Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453 | 分子名称: | Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Qiao, A.N, Wu, S, Ye, S. | 登録日 | 2021-12-20 | 公開日 | 2022-12-21 | 最終更新日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Activation and signaling mechanism revealed by GPR119-G s complex structures. Nat Commun, 13, 2022
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7XAV
| Structure of somatostatin receptor 2 bound with lanreotide. | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L. | 登録日 | 2022-03-19 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discov, 8, 2022
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8HDO
| Structure of A2BR bound to synthetic agonists BAY 60-6583 | 分子名称: | 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide, Adenosine A2b receptor, CHOLESTEROL, ... | 著者 | Cai, H, Xu, Y, Xu, H.E, Jiang, Y. | 登録日 | 2022-11-05 | 公開日 | 2023-01-18 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists. Cell Discov, 8, 2022
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8JHY
| Cryo-EM structure of compound 9n bound ketone body receptor HCAR2-Gi signaling complex | 分子名称: | 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H. | 登録日 | 2023-05-25 | 公開日 | 2023-09-06 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation. Mol.Cell, 83, 2023
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8K8J
| Cannabinoid Receptor 1 bound to Fenofibrate coupling MiniGsq and Nb35 Complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Tang, W.Q, Wang, T.X, Li, F.H, Wang, J.Y. | 登録日 | 2023-07-30 | 公開日 | 2024-02-14 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Fenofibrate Recognition and G q Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1. Adv Sci, 11, 2024
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8W8Q
| Cryo-EM structure of the GPR101-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Sun, J.P, Gao, N, Yu, X, Wang, G.P, Yang, F, Wang, J.Y, Yang, Z, Guan, Y. | 登録日 | 2023-09-04 | 公開日 | 2024-01-03 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20, 2024
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7VUZ
| Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2 | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7EO2
| Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to FTY720p | 分子名称: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Y, Xu, Z, Ikuta, T. | 登録日 | 2021-04-21 | 公開日 | 2022-01-05 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18, 2022
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7YDM
| Cryo-EM structure of CD97/Gq complex | 分子名称: | Adhesion G protein-coupled receptor E5 subunit beta, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Y, Wang, N. | 登録日 | 2022-07-04 | 公開日 | 2023-07-12 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structural basis of CD97 activation and G-protein coupling. Cell Chem Biol, 30, 2023
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