4OED
| Crystal structure of AR-LBD bound with co-regulator peptide | 分子名称: | 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Protein BUD31 homolog, ... | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-13 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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8C6J
| Human spliceosomal PM5 C* complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | 著者 | Dybkov, O, Kastner, B, Luehrmann, R. | 登録日 | 2023-01-12 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins. Sci Adv, 9, 2023
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6ID1
| Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | 著者 | Zhang, X, Zhan, X, Yan, C, Shi, Y. | 登録日 | 2018-09-07 | 公開日 | 2019-03-13 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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6ID0
| Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | 著者 | Zhang, X, Zhan, X, Yan, C, Shi, Y. | 登録日 | 2018-09-07 | 公開日 | 2019-03-13 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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4OKB
| Crystal structure of W741L-AR-LBD bound with co-regulator peptide | 分子名称: | Androgen receptor, Protein BUD31 homolog, R-BICALUTAMIDE, ... | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-22 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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8I0V
| The cryo-EM structure of human post-Bact complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | 著者 | Zhan, X, Lu, Y, Shi, Y. | 登録日 | 2023-01-11 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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8I0R
| The cryo-EM structure of human Bact-I complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | 著者 | Zhan, X, Lu, Y, Shi, Y. | 登録日 | 2023-01-11 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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8I0T
| The cryo-EM structure of human Bact-III complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | 著者 | Zhan, X, Lu, Y, Shi, Y. | 登録日 | 2023-01-11 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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6ICZ
| Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | 著者 | Zhang, X, Zhan, X, Yan, C, Shi, Y. | 登録日 | 2018-09-07 | 公開日 | 2019-03-13 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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7QTT
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8Q7N
| cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | 登録日 | 2023-08-16 | 公開日 | 2024-01-24 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. Embo J., 43, 2024
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9FMD
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6QDV
| Human post-catalytic P complex spliceosome | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | 著者 | Fica, S.M, Oubridge, C, Wilkinson, M.E, Newman, A.J, Nagai, K. | 登録日 | 2019-01-03 | 公開日 | 2019-02-20 | 最終更新日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science, 363, 2019
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8I0U
| The cryo-EM structure of human Bact-IV complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | 著者 | Zhan, X, Lu, Y, Shi, Y. | 登録日 | 2023-01-11 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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6ZYM
| Human C Complex Spliceosome - High-resolution CORE | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Corepressor interacting with RBPJ 1, ... | 著者 | Bertram, K, Kastner, B. | 登録日 | 2020-08-02 | 公開日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome. Mol.Cell, 80, 2020
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6FF4
| human Bact spliceosome core structure | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | 著者 | Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H. | 登録日 | 2018-01-03 | 公開日 | 2018-08-29 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure and Conformational Dynamics of the Human Spliceosomal BactComplex. Cell, 172, 2018
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8I0P
| The cryo-EM structure of human pre-Bact complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | 著者 | Zhan, X, Lu, Y, Shi, Y. | 登録日 | 2023-01-11 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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8I0W
| The cryo-EM structure of human C complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Coiled-coil domain-containing protein 94, ... | 著者 | Zhan, X, Lu, Y, Shi, Y. | 登録日 | 2023-01-11 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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8RO2
| Integrative Structure of the human intron lariat Spliceosome (ILS'') | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ATP-dependent RNA helicase DHX15, CWF19-like protein 1, ... | 著者 | Rothe, P, Vorlaender, M.K, Plaschka, C. | 登録日 | 2024-01-11 | 公開日 | 2024-09-18 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Mechanism for the initiation of spliceosome disassembly. Nature, 632, 2024
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4OH6
| Crystal structure of T877A-AR-LBD bound with co-regulator peptide | 分子名称: | Androgen receptor, HYDROXYFLUTAMIDE, Protein BUD31 homolog, ... | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-17 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.56 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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5XJC
| Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Zhang, X, Yan, C, Hang, J, Finci, I.L, Lei, J, Shi, Y. | 登録日 | 2017-04-30 | 公開日 | 2017-07-05 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | An Atomic Structure of the Human Spliceosome Cell, 169, 2017
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7W5A
| The cryo-EM structure of human pre-C*-II complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | 著者 | Zhan, X, Lu, Y, Shi, Y. | 登録日 | 2021-11-29 | 公開日 | 2022-06-22 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
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7W59
| The cryo-EM structure of human pre-C*-I complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | 著者 | Zhan, X, Lu, Y, Shi, Y. | 登録日 | 2021-11-29 | 公開日 | 2022-06-22 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
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7ABF
| Human pre-Bact-1 spliceosome core structure | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | 登録日 | 2020-09-07 | 公開日 | 2020-12-09 | 最終更新日 | 2020-12-30 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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5YZG
| The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Zhan, X, Yan, C, Zhang, X, Lei, J, Shi, Y. | 登録日 | 2017-12-14 | 公開日 | 2018-08-08 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structure of a human catalytic step I spliceosome Science, 359, 2018
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