4C3J
 
 | | Structure of 14-subunit RNA polymerase I at 3.35 A resolution, crystal form C2-90 | | 分子名称: | DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14, ... | | 著者 | Fernandez-Tornero, C, Moreno-Morcillo, M, Rashid, U.J, Taylor, N.M.I, Ruiz, F.M, Gruene, T, Legrand, P, Steuerwald, U, Muller, C.W. | | 登録日 | 2013-08-24 | | 公開日 | 2013-10-23 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | Crystal Structure of the 14-Subunit RNA Polymerase I
Nature, 502, 2013
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2NVT
 | | RNA Polymerase II Elongation Complex in 150 mM Mg+2 with GMPCPP | | 分子名称: | 5'-D(*GP*TP*AP*CP*TP*TP*G)-3', 5'-D(P*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*TP*GP*GP*TP*CP*TP*T)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... | | 著者 | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | | 登録日 | 2006-11-13 | | 公開日 | 2006-12-12 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.36 Å) | | 主引用文献 | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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3GTL
 | | Backtracked RNA polymerase II complex with 13mer with G<>U mismatch | | 分子名称: | DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | | 登録日 | 2009-03-27 | | 公開日 | 2009-06-09 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.38 Å) | | 主引用文献 | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
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2YU9
 | | RNA polymerase II elongation complex in 150 mm MG+2 with UTP | | 分子名称: | 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ... | | 著者 | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | | 登録日 | 2007-04-06 | | 公開日 | 2007-04-24 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
Cell(Cambridge,Mass.), 127, 2006
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1TWH
 | | RNA polymerase II complexed with 2'dATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 14.2 kDa polypeptide, ... | | 著者 | Westover, K.D, Bushnell, D.A, Kornberg, R.D. | | 登録日 | 2004-06-30 | | 公開日 | 2004-11-16 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
Cell(Cambridge,Mass.), 119, 2004
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7ML2
 | | RNA polymerase II pre-initiation complex (PIC3) | | 分子名称: | BJ4_G0004860.mRNA.1.CDS.1, BJ4_G0050160.mRNA.1.CDS.1, DNA-directed RNA polymerase II subunit RPB11, ... | | 著者 | Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K. | | 登録日 | 2021-04-27 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
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7RIX
 | | RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 2 | | 分子名称: | 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | | 著者 | Oh, J, Dervan, P.B, Wang, D. | | 登録日 | 2021-07-20 | | 公開日 | 2022-01-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Proc.Natl.Acad.Sci.USA, 119, 2022
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2VUM
 | | Alpha-amanitin inhibited complete RNA polymerase II elongation complex | | 分子名称: | 5'-D(*AP*AP*AP*CP*TP*AP*CP*TP*TP*GP *AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *GP*TP*TP*AP*CP*GP*CP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*AP*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... | | 著者 | Brueckner, F, Cramer, P. | | 登録日 | 2008-05-27 | | 公開日 | 2008-06-17 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural Basis of Transcription Inhibition by Alpha-Amanitin and Implications for RNA Polymerase II Translocation.
Nat.Struct.Mol.Biol., 15, 2008
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6UPX
 | | RNA polymerase II elongation complex with 5-guanidinohydantoin lesion in state 1 | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Oh, J, Wang, D. | | 登録日 | 2019-10-18 | | 公開日 | 2020-06-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-pi and CH-pi interactions.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6EU1
 | | RNA Polymerase III - open DNA complex (OC-POL3). | | 分子名称: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | | 著者 | Abascal-Palacios, G, Ramsay, E.P, Beuron, F, Morris, E, Vannini, A. | | 登録日 | 2017-10-27 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of RNA polymerase III transcription initiation.
Nature, 553, 2018
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6EU2
 | | Apo RNA Polymerase III - open conformation (oPOL3) | | 分子名称: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | | 著者 | Abascal-Palacios, G, Ramsay, E.P, Beuron, F, Morris, E, Vannini, A. | | 登録日 | 2017-10-27 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of RNA polymerase III transcription initiation.
Nature, 553, 2018
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8UKS
 | | RNA polymerase II elongation complex with Fapy-dG lesion soaking with CTP before chemistry | | 分子名称: | CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | | 著者 | Hou, P, Oh, J, Wang, D. | | 登録日 | 2023-10-15 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy·dG.
J.Am.Chem.Soc., 146, 2024
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5N61
 | | RNA polymerase I initially transcribing complex | | 分子名称: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | 著者 | Engel, C, Gubbey, T, Neyer, S, Sainsbury, S, Oberthuer, C, Baejen, C, Bernecky, C, Cramer, P. | | 登録日 | 2017-02-14 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural Basis of RNA Polymerase I Transcription Initiation.
Cell, 169, 2017
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2NVY
 | | RNA Polymerase II form II in 150 mM Mn+2 | | 分子名称: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 45 kDa polypeptide, ... | | 著者 | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | | 登録日 | 2006-11-13 | | 公開日 | 2006-12-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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4A3E
 | | RNA Polymerase II initial transcribing complex with a 5nt DNA-RNA hybrid and soaked with AMPCPP | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, ... | | 著者 | Cheung, A.C.M, Sainsbury, S, Cramer, P. | | 登録日 | 2011-09-30 | | 公開日 | 2011-12-07 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural basis of initial RNA polymerase II transcription.
EMBO J., 30, 2011
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4A93
 | | RNA Polymerase II elongation complex containing a CPD Lesion | | 分子名称: | 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*CP*T*TTP*TP*TP*CP*C BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-D(*TP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*TP)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP*AP)-3', ... | | 著者 | Walmacq, C, Cheung, A.C.M, Kireeva, M.L, Lubkowska, L, Ye, C, Gotte, D, Strathern, J.N, Carell, T, Cramer, P, Kashlev, M. | | 登録日 | 2011-11-23 | | 公開日 | 2012-03-21 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Mechanism of Translesion Transcription by RNA Polymerase II and its Role in Cellular Resistance to DNA Damage.
Mol.Cell, 46, 2012
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6UPY
 | | RNA polymerase II elongation complex with 5-guanidinohydantoin lesion in state 2E | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | | 著者 | Oh, J, Wang, D. | | 登録日 | 2019-10-18 | | 公開日 | 2020-06-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-pi and CH-pi interactions.
Proc.Natl.Acad.Sci.USA, 117, 2020
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3HOY
 | | Complete RNA polymerase II elongation complex VI | | 分子名称: | 5'-D(*CP*CP*AP*AP*GP*CP*TP*CP*AP*AP*G*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*TP*AP*CP*TP*AP*GP*TP*AP*CP*TP*GP*CP*C)-3', 5'-D(*CP*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*AP*GP*TP*AP*AP*AP*CP*TP*AP*GP*TP*AP*TP*T*GP*AP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*TP*T)-3', 5'-R(*UP*AP*UP*AP*UP*GP*CP*A*UP*AP*AP*AP*GP*AP*CP*CP*AP*GP*GP*A)-3', ... | | 著者 | Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P. | | 登録日 | 2009-06-03 | | 公開日 | 2009-07-28 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA.
Mol.Cell, 34, 2009
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7O72
 | | Yeast RNA polymerase II transcription pre-initiation complex with closed promoter DNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Schilbach, S, Aibara, S, Dienemann, C, Grabbe, F, Cramer, P. | | 登録日 | 2021-04-12 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
Cell, 184, 2021
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7O73
 | | Yeast RNA polymerase II transcription pre-initiation complex with closed distorted promoter DNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Schilbach, S, Aibara, S, Dienemann, C, Grabbe, F, Cramer, P. | | 登録日 | 2021-04-12 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
Cell, 184, 2021
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7Z1M
 | | Structure of yeast RNA Polymerase III Elongation Complex (EC) | | 分子名称: | (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | 著者 | Girbig, M, Mueller, C.W. | | 登録日 | 2022-02-24 | | 公開日 | 2022-08-31 | | 最終更新日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals.
Cell Rep, 40, 2022
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4A3D
 | | RNA Polymerase II initial transcribing complex with a 6nt DNA-RNA hybrid | | 分子名称: | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... | | 著者 | Cheung, A.C.M, Sainsbury, S, Cramer, P. | | 登録日 | 2011-09-30 | | 公開日 | 2011-12-07 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural basis of initial RNA polymerase II transcription.
EMBO J., 30, 2011
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4BBR
 | | Structure of RNA polymerase II-TFIIB complex | | 分子名称: | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... | | 著者 | Sainsbury, S, Niesser, J, Cramer, P. | | 登録日 | 2012-09-27 | | 公開日 | 2012-11-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structure and Function of the Initially Transcribing RNA Polymerase II-TFIIB Complex
Nature, 493, 2013
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6BLO
 | | Pol II elongation complex with an abasic lesion at i+1 position | | 分子名称: | DNA (5'-D(P*AP*(3DR)P*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | | 著者 | Wang, W, Wang, D. | | 登録日 | 2017-11-10 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.401 Å) | | 主引用文献 | Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BM2
 | | Pol II elongation complex with an abasic lesion at i-1 position | | 分子名称: | DNA (5'-D(P*CP*AP*(3DR)P*CP*TP*CP*TP*TP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | | 著者 | Wang, W, Wang, D. | | 登録日 | 2017-11-13 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.403 Å) | | 主引用文献 | Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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