6UPX

RNA polymerase II elongation complex with 5-guanidinohydantoin lesion in state 1

Summary for 6UPX

• Entry DOI: 10.2210/pdb6upx/pdb
• Descriptor: RNA, DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerases I, II, and III subunit RPABC5, ... (15 entities in total)
• Functional Keywords: rna polymerase ii, 5-guanidinohydantoin, elongation complex, dna lesion, transcription, transcription-rna-dna complex, transcription/rna/dna
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); More
• Total number of polymer chains: 13
• Total formula weight: 487517.68

Authors

Oh, J.,Wang, D. (deposition date: 2019-10-18, release date: 2020-06-10, Last modification date: 2023-10-11)

• Primary citation: Oh, J.,Fleming, A.M.,Xu, J.,Chong, J.,Burrows, C.J.,Wang, D.; RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-pi and CH-pi interactions.; Proc.Natl.Acad.Sci.USA, 117:9338-9348, 2020; PubMed: 32284409; DOI: 10.1073/pnas.1919904117

Experimental method

X-RAY DIFFRACTION (3.4 Å)