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PDB: 132 件

7YNG
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CR-bound alpha-synuclein fibrils
分子名称: Alpha-synuclein
著者Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D.
登録日2022-07-30
公開日2023-08-02
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献CR-bound alpha-synuclein fibrils
To Be Published
6RT0
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cryo-em structure of alpha-synuclein fibril polymorph 2A
分子名称: Alpha-synuclein
著者Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H.
登録日2019-05-22
公開日2019-06-26
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.
Elife, 8, 2019
7STX
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Cryo-EM structure of human NatB in complex with CoA-Alpha-Synuclein
分子名称: ACETYL GROUP, Alpha-synuclein, COENZYME A, ...
著者Deng, S, Marmorstein, R.
登録日2021-11-15
公開日2021-12-22
最終更新日2023-07-05
実験手法ELECTRON MICROSCOPY (3.14 Å)
主引用文献Cryo-EM structure of human NatB in complex with CoA-Alpha-Synuclein
Not Published
7NCK
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Type 3 alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 5
分子名称: Alpha-synuclein
著者Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
登録日2021-01-28
公開日2021-02-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.18 Å)
主引用文献Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy.
Febs Open Bio, 11, 2021
7LC9
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Cryo-EM structure of the N-terminal alpha-synuclein truncation 41-140
分子名称: Alpha-synuclein
著者Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L.
登録日2021-01-10
公開日2021-09-15
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The N terminus of alpha-synuclein dictates fibril formation.
Proc.Natl.Acad.Sci.USA, 118, 2021
8CZ6
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CryoEM structure of amplified alpha-synuclein fibril class A type I with extended core from DLB case X
分子名称: Alpha-synuclein
著者Zhou, Y, Sokratian, A, Xu, E, Viverette, E, Dillard, L, Yuan, Y, Li, J.Y, Matarangas, A, Bouvette, J, Borgnia, M, Bartesaghi, A, West, A.
登録日2022-05-24
公開日2023-05-31
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural and functional landscape of alpha-synuclein fibril assemblies amplified from cerebrospinal fluid
To Be Published
8CZ3
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CryoEM structure of amplified alpha-synuclein fibril class B type I with extended core from DLB case X
分子名称: Alpha-synuclein
著者Zhou, Y, Sokratian, A, Xu, E, Viverette, E, Dillard, L, Yuan, Y, Li, J.Y, Matarangas, A, Bouvette, J, Borgnia, M, Bartesaghi, A, West, A.
登録日2022-05-24
公開日2023-05-31
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural and functional landscape of alpha-synuclein fibril assemblies amplified from cerebrospinal fluid
To Be Published
8RQM
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Alpha-synuclein amyloid fibrils
分子名称: Alpha-synuclein
著者Saibil, H.R, Monistrol, J.
登録日2024-01-18
公開日2024-02-28
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly
Biorxiv, 2024
7V4A
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Heparin-induced alpha-synuclein fibrils polymorph 1
分子名称: Alpha-synuclein
著者Tao, Y.Q, Sun, Y.P, Liu, C, Li, D.
登録日2021-08-12
公開日2022-08-17
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Heparin-induced alpha-synuclein fibrils polymorph 1
To Be Published
8HZC
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Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-2)
分子名称: Alpha-synuclein
著者Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D.
登録日2023-01-08
公開日2024-01-10
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-2)
To Be Published
8HZB
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Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-1)
分子名称: Alpha-synuclein
著者Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D.
登録日2023-01-08
公開日2024-01-10
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-1)
To Be Published
6L1T
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Cryo-EM structure of phosphorylated Tyr39 a-synuclein amyloid fibril
分子名称: Alpha-synuclein
著者Liu, C, Li, Y.M, Zhao, K, Lim, Y.J, Liu, Z.Y.
登録日2019-09-30
公開日2020-08-12
最終更新日2020-09-02
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
8ADU
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Lipidic alpha-synuclein fibril - polymorph L1A
分子名称: Alpha-synuclein
著者Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F.
登録日2022-07-11
公開日2022-10-12
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献The 3D structure of lipidic fibrils of alpha-synuclein.
Nat Commun, 13, 2022
8PK2
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Cryo EM structure of the type 1m polymorph of alpha-synuclein
分子名称: Alpha-synuclein
著者Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
登録日2023-06-24
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation
Elife, 2023
6XYP
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Multiple system atrophy Type II-1 alpha-synuclein filament
分子名称: Alpha-synuclein
著者Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M.
登録日2020-01-30
公開日2020-02-12
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
6PEO
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Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril
分子名称: Alpha-synuclein
著者Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S.
登録日2019-06-20
公開日2019-11-27
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs.
Nat.Struct.Mol.Biol., 26, 2019
7OZG
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BU of 7ozg by Molmil
PMCA-amplified alpha-synuclein fibril polymorph, Parkinson's Disease patient-derived seeds
分子名称: Alpha-synuclein
著者Frieg, B, Geraets, J.A, Schroeder, G.F.
登録日2021-06-28
公開日2022-07-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献alpha-synuclein polymorphism determines oligodendroglial dysfunction
To Be Published
7V4C
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BU of 7v4c by Molmil
Heparin-induced alpha-synuclein fibrils polymorph 4
分子名称: Alpha-synuclein
著者Tao, Y.Q, Sun, Y.P, Liu, C, Li, D.
登録日2021-08-12
公開日2022-08-17
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Heparin-induced alpha-synuclein fibrils polymorph 4
To Be Published
8PK4
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Cryo EM structure of the type 5A polymorph of alpha-synuclein.
分子名称: Alpha-synuclein
著者Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
登録日2023-06-24
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation
Elife, 2023
8RI9
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BU of 8ri9 by Molmil
Late alpha-Synuclein fibril structure from liquid-liquid phase separations.
分子名称: Alpha-synuclein
著者De Simone, A, Barritt, J.D, Chen, S, Cascella, R, Cecchi, C, Bigi, A, Jarvis, J.A, Chiti, F, Dobson, C.M, Fusco, G.
登録日2023-12-18
公開日2024-03-06
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure-Toxicity Relationship in Intermediate Fibrils from alpha-Synuclein Condensates.
J.Am.Chem.Soc., 146, 2024
8HZS
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Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3)
分子名称: Alpha-synuclein
著者Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D.
登録日2023-01-09
公開日2024-01-10
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3)
To Be Published
6L1U
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BU of 6l1u by Molmil
Cryo-EM structure of phosphorylated Tyr39 alpha-synuclein amyloid fibril
分子名称: Alpha-synuclein
著者Liu, C, Li, Y.M, Zhao, K, Lim, Y.J, Liu, Z.Y.
登録日2019-09-30
公開日2020-08-12
最終更新日2020-09-02
実験手法ELECTRON MICROSCOPY (3.37 Å)
主引用文献Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
6L4S
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cryo-em structure of alpha-synuclein fiber mutation type E46K
分子名称: Alpha-synuclein
著者Li, Y.W, Zhao, K, Liu, C, Li, X.
登録日2019-10-21
公開日2020-04-29
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.37 Å)
主引用文献Parkinson's disease associated mutation E46K of alpha-synuclein triggers the formation of a distinct fibril structure.
Nat Commun, 11, 2020
7UAK
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Structure of recombinantly assembled A53E alpha-synuclein fibrils
分子名称: Alpha-synuclein
著者Zhou, K, Zhou, H.
登録日2022-03-13
公開日2023-03-29
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Cryo-EM structure of amyloid fibril formed by alpha-synuclein hereditary A53E mutation reveals a distinct protofilament interface.
J.Biol.Chem., 299, 2023
8G0L
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Semi-synthetic CoA-alpha-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies
分子名称: Alpha-synuclein, CARBOXYMETHYL COENZYME *A, N-alpha-acetyltransferase 20, ...
著者Gardner, S.M, Marmorstein, R.
登録日2023-01-31
公開日2023-05-03
実験手法ELECTRON MICROSCOPY (3.39 Å)
主引用文献Semi-synthetic CoA-alpha-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
Biorxiv, 2023

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件を2024-06-26に公開中

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