6L4S

cryo-em structure of alpha-synuclein fiber mutation type E46K

Summary for 6L4S

• Entry DOI: 10.2210/pdb6l4s/pdb
• EMDB information: 0833
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: alpha-syn fiber, parkinson disease, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 32412.94

Authors

Li, Y.W.,Zhao, K.,Liu, C.,Li, X. (deposition date: 2019-10-21, release date: 2020-04-29, Last modification date: 2021-11-10)

• Primary citation: Zhao, K.,Li, Y.,Liu, Z.,Long, H.,Zhao, C.,Luo, F.,Sun, Y.,Tao, Y.,Su, X.D.,Li, D.,Li, X.,Liu, C.; Parkinson's disease associated mutation E46K of alpha-synuclein triggers the formation of a distinct fibril structure.; Nat Commun, 11:2643-2643, 2020; PubMed: 32457390; DOI: 10.1038/s41467-020-16386-3

Experimental method

ELECTRON MICROSCOPY (3.37 Å)