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PDB: 8 件

3COG
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BU of 3cog by Molmil
Crystal structure of human cystathionase (Cystathionine gamma lyase) in complex with DL-propargylglycine
分子名称: (2S)-2-aminopent-4-enoic acid, Cystathionine gamma-lyase, DI(HYDROXYETHYL)ETHER, ...
著者Collins, R, Karlberg, T, Lehtio, L, Arrowsmith, C.H, Berglund, H, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Olesen, K, Persson, C, Schuler, H, Svensson, L, Thorsell, A.G, Tresaugues, L, Van den Berg, S, Sagermark, J, Busam, R.D, Welin, M, Weigelt, J, Wikstrom, M, Structural Genomics Consortium (SGC)
登録日2008-03-28
公開日2008-05-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S.
J.Biol.Chem., 284, 2009
5TSU
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Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
分子名称: CYSTEINE, Cystathionine gamma-lyase, METHIONINE, ...
著者Yan, W, Zhang, Y.
登録日2016-10-31
公開日2017-10-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
3ELP
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Structure of cystationine gamma lyase
分子名称: Cystathionine gamma-lyase
著者Sun, Q, Sivaraman, J.
登録日2008-09-23
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S
J.Biol.Chem., 284, 2009
6NBA
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BU of 6nba by Molmil
Crystal structure of Human Cystathionine gamma lyase with S-3-Carboxpropyl-L-Cysteine
分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine gamma-lyase
著者Kim, H, Yadav, P.K, Banerjee, R, Cho, U.-S.
登録日2018-12-06
公開日2019-06-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.495 Å)
主引用文献S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine gamma-lyase-dependent hydrogen sulfide synthesis.
J.Biol.Chem., 294, 2019
2NMP
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BU of 2nmp by Molmil
Crystal structure of human Cystathionine gamma lyase
分子名称: Cystathionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE
著者Karlberg, T, Uppenberg, J, Arrowsmith, C, Berglund, H, Busam, R.D, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Hogbom, M, Johansson, I, Kotenyova, T, Magnusdottir, A, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, van-den-Berg, S, Wallden, K, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC)
登録日2006-10-23
公開日2006-11-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S
J.Biol.Chem., 284, 2009
5EIG
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Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine
分子名称: CYSTEINE, Cystathionine gamma-lyase, SULFATE ION
著者Yan, W, Zhang, J.
登録日2015-10-29
公開日2016-11-09
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Systemic Depletion of Serum L-Cyst(e)ine with an Engineered Human Enzyme Mediates Potent Induction of ROS and Cancer Ablation
To Be Published
6OVG
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BU of 6ovg by Molmil
L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism
分子名称: Cystathionine gamma-lyase, SULFATE ION
著者Yan, W, Irani, S, Zhang, J.
登録日2019-05-07
公開日2020-04-22
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.719 Å)
主引用文献Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Proc.Natl.Acad.Sci.USA, 117, 2020
5TT2
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Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
分子名称: Cystathionine gamma-lyase, SULFATE ION
著者Yan, W, Zhang, Y.
登録日2016-10-31
公開日2017-10-11
最終更新日2019-11-27
実験手法X-RAY DIFFRACTION (2.949 Å)
主引用文献Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017

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