3COG

Crystal structure of human cystathionase (Cystathionine gamma lyase) in complex with DL-propargylglycine

Summary for 3COG

• Entry DOI: 10.2210/pdb3cog/pdb
• Related: 2NMP
• Descriptor: Cystathionine gamma-lyase, NITRATE ION, PYRIDOXAL-5'-PHOSPHATE, ... (7 entities in total)
• Functional Keywords: cth, plp, propargylglycine, sgc, inhibitor, structural genomics, sgc stockholm, structural genomics consortium, amino-acid biosynthesis, cysteine biosynthesis, disease mutation, lyase, phosphoprotein, pyridoxal phosphate
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P32929
• Total number of polymer chains: 4
• Total formula weight: 179182.11

Authors

Collins, R.,Karlberg, T.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Kallas, A.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Olesen, K.,Persson, C.,Schuler, H.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van den Berg, S.,Sagermark, J.,Busam, R.D.,Welin, M.,Weigelt, J.,Wikstrom, M.,Structural Genomics Consortium (SGC) (deposition date: 2008-03-28, release date: 2008-05-27, Last modification date: 2023-08-30)

• Primary citation: Sun, Q.,Collins, R.,Huang, S.,Holmberg-Schiavone, L.,Anand, G.S.,Tan, C.H.,van-den-Berg, S.,Deng, L.W.,Moore, P.K.,Karlberg, T.,Sivaraman, J.; Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S.; J.Biol.Chem., 284:3076-3085, 2009; PubMed: 19019829; DOI: 10.1074/jbc.M805459200

Experimental method

X-RAY DIFFRACTION (2 Å)