3COG
Crystal structure of human cystathionase (Cystathionine gamma lyase) in complex with DL-propargylglycine
Summary for 3COG
Entry DOI | 10.2210/pdb3cog/pdb |
Related | 2NMP |
Descriptor | Cystathionine gamma-lyase, NITRATE ION, PYRIDOXAL-5'-PHOSPHATE, ... (7 entities in total) |
Functional Keywords | cth, plp, propargylglycine, sgc, inhibitor, structural genomics, sgc stockholm, structural genomics consortium, amino-acid biosynthesis, cysteine biosynthesis, disease mutation, lyase, phosphoprotein, pyridoxal phosphate |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P32929 |
Total number of polymer chains | 4 |
Total formula weight | 179182.11 |
Authors | Collins, R.,Karlberg, T.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Kallas, A.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Olesen, K.,Persson, C.,Schuler, H.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van den Berg, S.,Sagermark, J.,Busam, R.D.,Welin, M.,Weigelt, J.,Wikstrom, M.,Structural Genomics Consortium (SGC) (deposition date: 2008-03-28, release date: 2008-05-27, Last modification date: 2023-08-30) |
Primary citation | Sun, Q.,Collins, R.,Huang, S.,Holmberg-Schiavone, L.,Anand, G.S.,Tan, C.H.,van-den-Berg, S.,Deng, L.W.,Moore, P.K.,Karlberg, T.,Sivaraman, J. Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S. J.Biol.Chem., 284:3076-3085, 2009 Cited by PubMed: 19019829DOI: 10.1074/jbc.M805459200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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