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PDB: 224 件
8H8Q
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Fab-amyloid beta fragment complex at neutral pH
分子名称: CHLORIDE ION, Fab, GLN-LYS-CYS-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-CYS-GLY, ...
著者Kita, A, Irie, K, Irie, Y, Matsushima, Y, Miki, K.
登録日2022-10-24
公開日2023-10-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Fab-amyloid beta fragment complex at neutral pH
To Be Published
6CO3
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aducanumab abeta complex
分子名称: ALA-GLU-PHE-ARG-HIS-ASP, Fab heavy chain, Fab light chain, ...
著者Arndt, J.W.
登録日2018-03-10
公開日2018-05-02
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.384 Å)
主引用文献Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
7E6P
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BU of 7e6p by Molmil
Fab-amyloid beta fragment complex
分子名称: 1,2-ETHANEDIOL, Amyloid beta fragment with an intramolecular disulfide bond at positions 17 and 28, DI(HYDROXYETHYL)ETHER, ...
著者Kita, A, Irie, K, Irie, Y, Miki, K.
登録日2021-02-23
公開日2022-01-05
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Characterization of a Conformation-Restricted Amyloid beta Peptide and Immunoreactivity of Its Antibody in Human AD brain.
Acs Chem Neurosci, 12, 2021
5ONQ
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Alzheimer's Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd-substituted Thermolysin
分子名称: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
著者Leite, J.P, Gales, L.
登録日2017-08-04
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.17 Å)
主引用文献Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
5HOW
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BU of 5how by Molmil
X-ray crystallographic structure of an Abeta 17-36 beta-hairpin. LV(PHI)FAEDCGSNKCAII(SAR)L(ORN)V
分子名称: Amyloid beta A4 protein
著者Kreutzer, A.G, Nowick, J.S, Spencer, R.K.
登録日2016-01-19
公開日2016-03-23
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (2.295 Å)
主引用文献X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138, 2016
7WFY
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BU of 7wfy by Molmil
Crystal Structure of the VAV2 SH2 domain in complex with APP phosphorylated peptide
分子名称: Amyloid beta A4 protein-binding family B member 1 (protein), Guanine nucleotide exchange factor VAV2
著者Zhang, Y.J, Liu, Y.R, Wu, B.
登録日2021-12-27
公開日2022-12-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.449 Å)
主引用文献Vav2 is a novel APP-interacting protein that regulates APP protein level.
Sci Rep, 12, 2022
7Y3J
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24B3 antibody-peptide complex
分子名称: 24B3 Heavy chain, 24B3 Light chain, ALA-LEU-VAL-PHE-PHE-ALA-PRO-ALA-VAL-GLY-SER
著者Irie, K, Irie, Y, Kita, A, Miki, K.
登録日2022-06-11
公開日2022-08-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis of the 24B3 antibody against the toxic conformer of amyloid beta with a turn at positions 22 and 23.
Biochem.Biophys.Res.Commun., 621, 2022
8T82
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Racemic mixture of amyloid beta segment 35-MVGGVV-40 forms heterochiral rippled beta-sheet, includes pentafluoropropionic acid
分子名称: amyloid beta segment 35-MVGGVV-40, racemic mixture, pentafluoropropanoic acid
著者Sawaya, M.R, Raskatov, J.A, Hazari, A.
登録日2023-06-21
公開日2023-11-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Racemic Peptides from Amyloid beta and Amylin Form Rippled beta-Sheets Rather Than Pleated beta-Sheets.
J.Am.Chem.Soc., 145, 2023
8T89
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Racemic mixture of amyloid beta segment 16-KLVFFA-21 forms heterochiral rippled beta-sheet
分子名称: Racemic mixture of amyloid beta segment 16-KLVFFA-21, trifluoroacetic acid
著者Sawaya, M.R, Raskatov, J.A, Hazari, A.
登録日2023-06-22
公開日2023-11-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Racemic Peptides from Amyloid beta and Amylin Form Rippled beta-Sheets Rather Than Pleated beta-Sheets.
J.Am.Chem.Soc., 145, 2023
3JQL
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BU of 3jql by Molmil
Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution
分子名称: Acidic phospholipase A2 3 (Fragment), Amyloid Beta Peptide, CALCIUM ION
著者Mirza, Z, Vikram, G, Singh, N, Sinha, M, Sharma, S, Srinivasan, A, Kaur, P, Singh, T.P.
登録日2009-09-07
公開日2009-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution
To be Published
3JQ5
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Phospholipase A2 Prevents the Aggregation of Amyloid Beta Peptides: Crystal Structure of the Complex of Phospholipase A2 with Octapeptide Fragment of Amyloid Beta Peptide, Asp-Ala-Glu-Phe-Arg-His-Asp-Ser at 2 A Resolution
分子名称: Amyloid Beta Peptide, CALCIUM ION, Phospholipase A2 isoform 3
著者Mirza, Z, Vikram, G, Singh, N, Sinha, M, Bhushan, A, Sharma, S, Srinivasan, A, Kaur, P, Singh, T.P.
登録日2009-09-06
公開日2009-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Phospholipase A2 Prevents the Aggregation of Amyloid Beta Peptides: Crystal Structure of the Complex of Phospholipase A2 with Octapeptide Fragment of Amyloid Beta Peptide, Asp-Ala-Glu-Phe-Arg-His-Asp-Ser at 2 A Resolution
To be Published
5MY4
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BU of 5my4 by Molmil
Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with human Abeta-pE3-12PEGb
分子名称: Fab c#17 heavy chain, Fab c#17 light chain, Pyroglutamate-Abeta pE3-12-PEGb
著者Parthier, C, Piechotta, A, Stubbs, M.T.
登録日2017-01-25
公開日2017-06-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.211 Å)
主引用文献Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017
5MYX
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Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18
分子名称: Fab c#24 heavy chain, Fab c#24 light chain, Pyroglutamate-Abeta pE3-18
著者Parthier, C, Piechotta, A, Stubbs, M.T.
登録日2017-01-30
公開日2017-06-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.492 Å)
主引用文献Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017
5ONP
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Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Cd-substituted Thermolysin
分子名称: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
著者Leite, J.P, Gales, L.
登録日2017-08-04
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
8I4O
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BU of 8i4o by Molmil
Design of a split green fluorescent protein for sensing and tracking an beta-amyloid
分子名称: Beta-amyloid, Split Green flourescent protein
著者Taegeun, Y, Jinsu, L, Jungmin, Y, Jungmin, C, Wondo, H, Song, J.J, Haksung, K.
登録日2023-01-20
公開日2023-11-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Engineering of a Fluorescent Protein for a Sensing of an Intrinsically Disordered Protein through Transition in the Chromophore State.
Jacs Au, 3, 2023
3BKJ
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BU of 3bkj by Molmil
Crystal structure of Fab wo2 bound to the n terminal domain of amyloid beta peptide (1-16)
分子名称: Amyloid Beta Peptide, WO2 IgG2a Fab fragment Heavy Chain, WO2 IgG2a Fab fragment Light Chain Kappa
著者Miles, L.A, Wun, K.S, Crespi, G.A, Fodero-Tavoletti, M, Galatis, D, Bageley, C.J, Beyreuther, K, Masters, C.L, Cappai, R, McKinstry, W.J, Barnham, K.J, Parker, M.W.
登録日2007-12-06
公開日2008-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.
J.Mol.Biol., 377, 2008
2G47
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Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)
分子名称: 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, amyloid protein beta A4
著者Shen, Y, Tang, W.-J.
登録日2006-02-21
公開日2006-10-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
8B9Q
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BU of 8b9q by Molmil
Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease
分子名称: Amyloid-beta A4 protein, COPPER (II) ION
著者Abelein, A, Ciofi-Baffoni, S, Kumar, R, Giachetti, A, Piccioli, M, Biverstal, H.
登録日2022-10-06
公開日2023-02-08
最終更新日2024-06-05
実験手法SOLUTION NMR
主引用文献Molecular Structure of Cu(II)-Bound Amyloid-beta Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease.
Jacs Au, 2, 2022
6ITU
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BU of 6itu by Molmil
Crystal Structure of the GULP1 PTB domain-APP peptide complex
分子名称: 1,2-ETHANEDIOL, Amyloid beta A4 protein, PTB domain-containing engulfment adapter protein 1, ...
著者Yung, K.W.Y, Lau, K.F, Ngo, J.C.K.
登録日2018-11-26
公開日2019-08-14
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Attenuation of amyloid-beta generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.
Faseb J., 33, 2019
7F29
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Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42)
分子名称: ACETIC ACID, Amyloid-beta A4 protein, beta-D-galactopyranose-(1-3)-2-amino-2-deoxy-alpha-D-galactopyranose
著者Xia, W.C, Sun, Y.P, Liu, C.
登録日2021-06-10
公開日2022-07-13
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献O-Glycosylation Induces Amyloid-beta To Form New Fibril Polymorphs Vulnerable for Degradation
J.Am.Chem.Soc., 143, 2021
5ONR
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BU of 5onr by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Thermolysin
分子名称: Amyloid-beta A4 protein, CALCIUM ION, DIMETHYL SULFOXIDE, ...
著者Leite, J.P, Gales, L.
登録日2017-08-04
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
5HOY
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BU of 5hoy by Molmil
X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. X-ray diffractometer data set. (LVFFAEDCGSNKCAII(SAR)LMV).
分子名称: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)
著者Kreutzer, A.G, Spencer, R.K, Nowick, J.S.
登録日2016-01-19
公開日2016-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.295 Å)
主引用文献X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138, 2016
5HOX
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X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. Synchrotron data set. (LVFFAEDCGSNKCAII(SAR)LMV).
分子名称: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)
著者Kreutzer, A.G, Nowick, J.S, Spencer, R.K.
登録日2016-01-19
公開日2016-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138, 2016
6OIZ
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BU of 6oiz by Molmil
Amyloid-Beta (20-34) wild type
分子名称: Amyloid beta A4 protein
著者Sawaya, M.R, Warmack, R.A, Zee, C.T, Gonen, T, Clarke, S.G, Eisenberg, D.S.
登録日2019-04-10
公開日2019-08-07
最終更新日2024-05-15
実験手法ELECTRON CRYSTALLOGRAPHY (1.1 Å)
主引用文献Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
7WVY
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Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2
分子名称: Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
登録日2022-02-11
公開日2022-04-13
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022

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