6ODG
| SVQIVY, Crystal Structure of a tau protein fragment | 分子名称: | Microtubule-associated protein tau | 著者 | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Seidler, P.M. | 登録日 | 2019-03-26 | 公開日 | 2019-10-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. J.Biol.Chem., 294, 2019
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8KDX
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5K7N
| MicroED structure of tau VQIVYK peptide at 1.1 A resolution | 分子名称: | VQIVYK | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | 登録日 | 2016-05-26 | 公開日 | 2017-04-05 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.1 Å) | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat. Methods, 14, 2017
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5V5C
| VQIINK, Structure of the amyloid-spine from microtubule associated protein tau Repeat 2 | 分子名称: | Microtubule-associated protein tau | 著者 | Seidler, P.M, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S, Cascio, D, Boyer, D.R. | 登録日 | 2017-03-14 | 公開日 | 2018-02-07 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.25 Å) | 主引用文献 | Structure-based inhibitors of tau aggregation. Nat Chem, 10, 2018
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6FAU
| Crystal structure of C-terminal modified Tau peptide-hybrid 4.2e-I with 14-3-3sigma | 分子名称: | (2~{R})-2-[(~{R})-(2-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | 登録日 | 2017-12-18 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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8GCK
| Crystal structure of the human CHIP-TPR domain in complex with a 6mer acetylated tau peptide | 分子名称: | ACE-SER-ILE-ASP-MET-VAL-ASP, E3 ubiquitin-protein ligase CHIP | 著者 | Wucherer, K, Bohn, M.F, Basu, K, Nadel, C.M, Gestwicki, J.E, Craik, C.S. | 登録日 | 2023-03-02 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.36823535 Å) | 主引用文献 | Intersecting PTMs regulate clearance of pathogenic tau by the ubiquitin ligase CHIP. To Be Published
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6FAW
| Crystal structure of C-terminal modified Tau peptide-hybrid 4.2c-I with 14-3-3sigma | 分子名称: | (2~{R})-2-[(~{R})-[2-(2-methoxyethoxy)phenyl]-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | 登録日 | 2017-12-18 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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4Y5I
| Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Microtubule-associated protein tau | 著者 | Leysen, S, Bartel, M, Milroy, L, Brunsveld, L, Ottmann, C. | 登録日 | 2015-02-11 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
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6FAV
| Crystal structure of C-terminal modified Tau peptide-hybrid 4.2f-I with 14-3-3sigma | 分子名称: | (2~{R})-2-[(~{R})-(3-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | 登録日 | 2017-12-18 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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6FBW
| Crystal structure of C-terminal modified Tau peptide-hybrid 4.2f-II with 14-3-3sigma | 分子名称: | (2~{R})-2-[(~{S})-(3-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | 登録日 | 2017-12-20 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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5V5B
| KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2 | 分子名称: | Microtubule-associated protein tau | 著者 | Seidler, P.M, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S, Cascio, D, Boyer, D.R. | 登録日 | 2017-03-13 | 公開日 | 2018-02-07 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.5 Å) | 主引用文献 | Structure-based inhibitors of tau aggregation. Nat Chem, 10, 2018
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5E2W
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6FBY
| Crystal structure of C-terminal modified Tau peptide-hybrid 4.2b with 14-3-3sigma | 分子名称: | (2~{R})-2-[(~{S})-(3-methylphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | 登録日 | 2017-12-20 | 公開日 | 2018-05-16 | 最終更新日 | 2019-02-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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4NP8
| Structure of an amyloid forming peptide VQIVYK from the second repeat region of tau (alternate polymorph) | 分子名称: | Microtubule-associated protein tau | 著者 | Landau, M, Eisenberg, D, Sawaya, M.R, Dannenberg, J, Kobko, N. | 登録日 | 2013-11-20 | 公開日 | 2013-12-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Molecular mechanisms for protein-encoded inheritance. Nat.Struct.Mol.Biol., 16, 2009
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2ON9
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8OP0
| VHH Z70 mutant 20 in interaction with PHF6 Tau peptide | 分子名称: | Tau PHF6 peptide, VHH Z70 mutant 20 | 著者 | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | 登録日 | 2023-04-06 | 公開日 | 2023-05-31 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein. J.Biol.Chem., 300, 2024
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6PXR
| Anti-TAU BIIB092 FAB with TAU peptide | 分子名称: | Microtubule-associated protein tau, gosuranemab Fab, heavy chain, ... | 著者 | Arndt, J.W, Quan, C. | 登録日 | 2019-07-26 | 公開日 | 2020-07-29 | 最終更新日 | 2021-02-10 | 実験手法 | X-RAY DIFFRACTION (1.556 Å) | 主引用文献 | Characterization of tau binding by gosuranemab. Neurobiol.Dis., 146, 2020
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4TQE
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5E2V
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4E0N
| SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form II) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN), PHOSPHATE ION | 著者 | Zhao, M, Liu, C, Michael, S.R, Eisenberg, D. | 登録日 | 2012-03-04 | 公開日 | 2012-12-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates. Proc.Natl.Acad.Sci.USA, 109, 2012
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5MO3
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6FI5
| Crystal structure of C-terminal modified Tau peptide-hybrid 3.2d with 14-3-3sigma | 分子名称: | (2~{S})-2-(diphenylmethyl)pyrrolidine, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | 登録日 | 2018-01-17 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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4Y32
| Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma | 分子名称: | (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-CNC(C(C)O)C(=O)N1CCCC1CCOC | 著者 | Bartel, M, Milroy, L, Bier, D, Brunsveld, L, Ottmann, C. | 登録日 | 2015-02-10 | 公開日 | 2015-12-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
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5BTV
| Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324 | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | 著者 | Ottmann, C, Schumacher, B, Bartel, M. | 登録日 | 2015-06-03 | 公開日 | 2016-07-20 | 最終更新日 | 2019-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. Faseb J., 29, 2015
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8Q98
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