8GCK

Crystal structure of the human CHIP-TPR domain in complex with a 6mer acetylated tau peptide

Summary for 8GCK

• Entry DOI: 10.2210/pdb8gck/pdb
• Related: 8FYU
• Descriptor: E3 ubiquitin-protein ligase CHIP, ACE-SER-ILE-ASP-MET-VAL-ASP (3 entities in total)
• Functional Keywords: e3 ligase, ligand, tpr domain, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 30741.01

Authors

Wucherer, K.,Bohn, M.F.,Basu, K.,Nadel, C.M.,Gestwicki, J.E.,Craik, C.S. (deposition date: 2023-03-02, release date: 2024-03-06, Last modification date: 2025-10-01)

• Primary citation: Nadel, C.M.,Gestwicki, J.E.; Intersecting PTMS regulate clearance of pathogenic tau by the CHIP ubiquitin ligase; Alzheimer's Dement., 18:-, 2022; DOI: 10.1002/alz.062036

Experimental method

X-RAY DIFFRACTION (1.36823537069 Å)