6FAV

Crystal structure of C-terminal modified Tau peptide-hybrid 4.2f-I with 14-3-3sigma

Summary for 6FAV

• Entry DOI: 10.2210/pdb6fav/pdb
• Related: 6FAU
• Descriptor: 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, THR-PRO-SEP-LEU-PRO-GLY, ... (7 entities in total)
• Functional Keywords: tau 14-3-3 alzheimer, structural protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 55290.88

Authors

Andrei, S.A.,Meijer, F.A.,Ottmann, C.,Milroy, L.G. (deposition date: 2017-12-18, release date: 2018-05-16, Last modification date: 2024-01-17)

• Primary citation: Andrei, S.A.,Meijer, F.A.,Neves, J.F.,Brunsveld, L.,Landrieu, I.,Ottmann, C.,Milroy, L.G.; Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.; ACS Chem Neurosci, 9:2639-2654, 2018; PubMed: 29722962; DOI: 10.1021/acschemneuro.8b00118

Experimental method

X-RAY DIFFRACTION (1.4 Å)