6FAU

Crystal structure of C-terminal modified Tau peptide-hybrid 4.2e-I with 14-3-3sigma

Summary for 6FAU

Entry DOI	10.2210/pdb6fau/pdb
Descriptor	14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, THR-PRO-SEP-LEU-PRO-GLY, ... (7 entities in total)
Functional Keywords	tau 14-3-3 alzheimer, structural protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	55336.86
Authors	Andrei, S.A.,Meijer, F.A.,Ottmann, C.,Milroy, L.G. (deposition date: 2017-12-18, release date: 2018-05-16, Last modification date: 2024-01-17)
Primary citation	Andrei, S.A.,Meijer, F.A.,Neves, J.F.,Brunsveld, L.,Landrieu, I.,Ottmann, C.,Milroy, L.G. Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9:2639-2654, 2018 Cited by PubMed: 29722962 DOI: 10.1021/acschemneuro.8b00118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation