4EA3
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![BU of 4ea3 by Molmil](/molmil-images/mine/4ea3) | Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)propyl]-D-prolinamide, ... | 著者 | Thompson, A.A, Liu, W, Chun, E, Katritch, V, Wu, H, Vardy, E, Huang, X.P, Trapella, C, Guerrini, R, Calo, G, Roth, B.L, Cherezov, V, Stevens, R.C, GPCR Network (GPCR) | 登録日 | 2012-03-22 | 公開日 | 2012-04-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.013 Å) | 主引用文献 | Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature, 485, 2012
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6M97
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8X2K
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![BU of 8x2k by Molmil](/molmil-images/mine/8x2k) | a lipid receptor complex structure | 分子名称: | (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Geng, C, Yang, D, Jun, X. | 登録日 | 2023-11-09 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | a lipid receptor complex structure To Be Published
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8HVI
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![BU of 8hvi by Molmil](/molmil-images/mine/8hvi) | Activation mechanism of GPR132 by compound NOX-6-7 | 分子名称: | 3-methyl-5-[(4-oxidanylidene-4-phenyl-butanoyl)amino]-1-benzofuran-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | 登録日 | 2022-12-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8DR8
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![BU of 8dr8 by Molmil](/molmil-images/mine/8dr8) | LRRC8A:C conformation 2 (oblong) top mask | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | 著者 | Kern, D.M, Brohawn, S.G. | 登録日 | 2022-07-20 | 公開日 | 2023-03-08 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8K9L
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![BU of 8k9l by Molmil](/molmil-images/mine/8k9l) | Full agonist- and positive allosteric modulator-bound mu-type opioid receptor-G protein complex | 分子名称: | (2~{S})-2-(3-bromanyl-4-methoxy-phenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine, DAMGO, G protein subunit alpha i3, ... | 著者 | Hisano, T, Uchikubo-Kamo, T, Shirouzu, M, Imai, S, Kaneko, S, Shimada, I. | 登録日 | 2023-08-01 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Structural and dynamic insights into the activation of the mu-opioid receptor by an allosteric modulator. Nat Commun, 15, 2024
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8JXX
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![BU of 8jxx by Molmil](/molmil-images/mine/8jxx) | Clobenpropit-bound H4R/Gi complex | 分子名称: | 3-(1~{H}-imidazol-4-yl)propyl ~{N}'-[(4-chlorophenyl)methyl]carbamimidothioate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Y, Xia, R. | 登録日 | 2023-07-01 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor. Nat Commun, 15, 2024
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8IHH
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![BU of 8ihh by Molmil](/molmil-images/mine/8ihh) | Cryo-EM structure of HCA2-Gi complex with LUF6283 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-butyl-1~{H}-pyrazole-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | 登録日 | 2023-02-22 | 公開日 | 2023-08-30 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
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8DS3
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![BU of 8ds3 by Molmil](/molmil-images/mine/8ds3) | LRRC8A:C conformation 1 (round) | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | 著者 | Kern, D.M, Brohawn, S.G. | 登録日 | 2022-07-21 | 公開日 | 2023-03-08 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8JXT
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![BU of 8jxt by Molmil](/molmil-images/mine/8jxt) | Histamine-bound H4R/Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | He, Y, Xia, R. | 登録日 | 2023-07-01 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor. Nat Commun, 15, 2024
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8IHJ
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![BU of 8ihj by Molmil](/molmil-images/mine/8ihj) | Cryo-EM structure of HCA3-Gi complex with acifran | 分子名称: | (5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | 登録日 | 2023-02-22 | 公開日 | 2023-08-30 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
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8ZSS
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![BU of 8zss by Molmil](/molmil-images/mine/8zss) | Cryo-EM structure of the RO5263397-bound hTAAR1-Gs complex | 分子名称: | (4~{S})-4-(3-fluoranyl-2-methyl-phenyl)-1,3-oxazolidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jiang, K.X, Zheng, Y, Xu, F. | 登録日 | 2024-06-05 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules. Cell Rep, 43, 2024
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8HS2
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![BU of 8hs2 by Molmil](/molmil-images/mine/8hs2) | Orphan GPR20 in complex with Fab046 | 分子名称: | Light chain of Fab046, Soluble cytochrome b562,G-protein coupled receptor 20, heavy chain of Fab046 | 著者 | Lin, X, Jiang, S, Xu, F. | 登録日 | 2022-12-16 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
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8ZFJ
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![BU of 8zfj by Molmil](/molmil-images/mine/8zfj) | cryo-EM structure of GPR4-Gs complex at pH 8.5 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Ma, Y, Tang, M, Ru, H, Song, G. | 登録日 | 2024-05-07 | 公開日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insight into CD93 recognition by IGFBP7. Structure, 32, 2024
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8F74
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![BU of 8f74 by Molmil](/molmil-images/mine/8f74) | LRRC8A(T48D):C conformation 2 top focus | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | 著者 | Kern, D.M, Brohawn, S.G. | 登録日 | 2022-11-18 | 公開日 | 2023-03-08 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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7F4I
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![BU of 7f4i by Molmil](/molmil-images/mine/7f4i) | Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35 | 分子名称: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. | 登録日 | 2021-06-18 | 公開日 | 2021-09-08 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
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8JLJ
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![BU of 8jlj by Molmil](/molmil-images/mine/8jlj) | T1AM-bound mTAAR1-Gs protein complex | 分子名称: | 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | 登録日 | 2023-06-02 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature, 624, 2023
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7WVW
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![BU of 7wvw by Molmil](/molmil-images/mine/7wvw) | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2 | 分子名称: | FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-02-11 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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6DRX
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![BU of 6drx by Molmil](/molmil-images/mine/6drx) | Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5HT2B receptor, BRIL chimera, ... | 著者 | McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L. | 登録日 | 2018-06-13 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural determinants of 5-HT2Breceptor activation and biased agonism. Nat. Struct. Mol. Biol., 25, 2018
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7X5H
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![BU of 7x5h by Molmil](/molmil-images/mine/7x5h) | Serotonin 5A (5-HT5A) receptor-Gi protein complex | 分子名称: | 3-(2-azanylethyl)-1H-indole-5-carboxamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Tan, Y, Xu, P, Huang, S, Xu, H.E, Jiang, Y. | 登録日 | 2022-03-04 | 公開日 | 2022-09-14 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into the ligand binding and G i coupling of serotonin receptor 5-HT 5A . Cell Discov, 8, 2022
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7DFP
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![BU of 7dfp by Molmil](/molmil-images/mine/7dfp) | Human dopamine D2 receptor in complex with spiperone | 分子名称: | 8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, D(2) dopamine receptor,Soluble cytochrome b562, FabH, ... | 著者 | Im, D, Shimamura, T, Iwata, S. | 登録日 | 2020-11-09 | 公開日 | 2020-12-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of the dopamine D 2 receptor in complex with the antipsychotic drug spiperone. Nat Commun, 11, 2020
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7XZ5
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![BU of 7xz5 by Molmil](/molmil-images/mine/7xz5) | GPR119-Gs-LPC complex | 分子名称: | (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | 登録日 | 2022-06-02 | 公開日 | 2022-08-24 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7Y13
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![BU of 7y13 by Molmil](/molmil-images/mine/7y13) | Cryo-EM structure of apo-state MrgD-Gi complex (local) | 分子名称: | PALMITIC ACID, Soluble cytochrome b562,Mas-related G-protein coupled receptor member D | 著者 | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | 登録日 | 2022-06-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
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5OLO
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![BU of 5olo by Molmil](/molmil-images/mine/5olo) | Structure of the A2A-StaR2-bRIL562-Tozadenant complex at 3.1A obtained from in meso soaking experiments. | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... | 著者 | Rucktooa, P, Cheng, R.K.Y, Segala, E, Geng, T, Errey, J.C, Brown, G.A, Cooke, R, Marshall, F.H, Dore, A.S. | 登録日 | 2017-07-28 | 公開日 | 2018-01-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals. Sci Rep, 8, 2018
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7E2Z
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![BU of 7e2z by Molmil](/molmil-images/mine/7e2z) | Aripiprazole-bound serotonin 1A (5-HT1A) receptor-Gi protein complex | 分子名称: | 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E. | 登録日 | 2021-02-07 | 公開日 | 2021-04-14 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into the lipid and ligand regulation of serotonin receptors. Nature, 592, 2021
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