8Z7N
 
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6X5B
 | | Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with small molecule GO52 | | 分子名称: | 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | | 登録日 | 2020-05-25 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide.
Cell Rep, 33, 2020
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7TXD
 | | Cryo-EM structure of BG505 SOSIP HIV-1 Env trimer in complex with CD4 receptor (D1D2) and broadly neutralizing darpin bnD.9 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Broadly neutralizing darpin bnd.9, ... | | 著者 | Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L. | | 登録日 | 2022-02-08 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | | 主引用文献 | Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.
Nat.Struct.Mol.Biol., 30, 2023
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2B4C
 | | Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, T-cell surface glycoprotein CD4, ... | | 著者 | Huang, C, Tang, M, Zhang, M.Y, Majeed, S, Montabana, E, Stanfield, R.L, Dimitrov, D.S, Korber, B, Sodroski, J, Wilson, I.A, Wyatt, R, Kwong, P.D. | | 登録日 | 2005-09-23 | | 公開日 | 2005-11-15 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure of a V3-containing HIV-1 gp120 core.
Science, 310, 2005
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2QAD
 | | Structure of tyrosine-sulfated 412d antibody complexed with HIV-1 YU2 gp120 and CD4 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | | 著者 | Huang, C.-C, Tang, M, Robinson, J, Wyatt, R, Kwong, P.D. | | 登録日 | 2007-06-14 | | 公開日 | 2007-09-25 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4
Science, 317, 2007
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6EDU
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8D5C
 | | anti-HIV-1 gp120-sCD4 complex antibody CG10 Fab in complex with B41-sCD4 | | 分子名称: | CG10 Fab heavy chain, CG10 Fab light chain, Envelope glycoprotein gp160, ... | | 著者 | Yang, Z, Bjorkman, P.J, Gershoni, J.M. | | 登録日 | 2022-06-04 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Antibody Recognition of CD4-Induced Open HIV-1 Env Trimers.
J.Virol., 96, 2022
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8W90
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4JM2
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6CM3
 | | BG505 SOSIP in complex with sCD4, 17b, 8ANC195 | | 分子名称: | 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wang, H, Bjorkman, P.J. | | 登録日 | 2018-03-02 | | 公開日 | 2018-10-17 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion.
Cell Host Microbe, 24, 2018
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5CAY
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4H8W
 | | Crystal structure of non-neutralizing and ADCC-potent antibody N5-i5 in complex with HIV-1 clade A/E gp120 and sCD4. | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB HEAVY CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, ... | | 著者 | Tolbert, W.D, Acharya, P, Kwong, P.D, Pazgier, M. | | 登録日 | 2012-09-24 | | 公開日 | 2014-04-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
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1JL4
 | | CRYSTAL STRUCTURE OF THE HUMAN CD4 N-TERMINAL TWO DOMAIN FRAGMENT COMPLEXED TO A CLASS II MHC MOLECULE | | 分子名称: | H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K ALPHA CHAIN, A-K BETA CHAIN, ... | | 著者 | Wang, J.-H, Meijers, R, Reinherz, E.L. | | 登録日 | 2001-07-15 | | 公開日 | 2001-09-19 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule.
Proc.Natl.Acad.Sci.USA, 98, 2001
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1Q68
 | | Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments | | 分子名称: | Proto-oncogene tyrosine-protein kinase LCK, T-cell surface glycoprotein CD4, ZINC ION | | 著者 | Kim, P.W, Sun, Z.Y, Blacklow, S.C, Wagner, G, Eck, M.J. | | 登録日 | 2003-08-12 | | 公開日 | 2003-11-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
Science, 301, 2003
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3JCB
 | | Structure of Simian Immunodeficiency Virus Envelope Spikes bound with CD4 and Monoclonal Antibody 36D5 | | 分子名称: | Antibody 36D5 heavy chain, Antibody 36D5 light chain, Envelope glycoprotein gp120, ... | | 著者 | Hu, G, Liu, J, Roux, K, Taylor, K.A. | | 登録日 | 2015-11-25 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY | | 主引用文献 | Structure of Simian Immunodeficiency Virus Envelope Spikes Bound with CD4 and Monoclonal Antibody 36D5.
J. Virol., 91, 2017
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6OPO
 | | Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with DDM | | 分子名称: | 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | | 登録日 | 2019-04-25 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide.
Cell Rep, 33, 2020
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6URI
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6OPQ
 | | CD4- and 17-bound HIV-1 Env B41 SOSIP frozen with LMNG | | 分子名称: | 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | | 登録日 | 2019-04-25 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide.
Cell Rep, 33, 2020
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6U0N
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3CD4
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6U0L
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8FYJ
 | | Structure of HIV-1 BG505 SOSIP-HT2 in complex with two CD4 molecules (class I) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | | 著者 | Fan, C, Dam, K.A, Bjorkman, P.J. | | 登録日 | 2023-01-26 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Intermediate conformations of CD4-bound HIV-1 Env heterotrimers.
Nature, 623, 2023
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8FYI
 | | Structure of HIV-1 BG505 SOSIP-HT1 in complex with one CD4 molecule | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(6-8)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Fan, C, Dam, K.A, Bjorkman, P.J. | | 登録日 | 2023-01-26 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Intermediate conformations of CD4-bound HIV-1 Env heterotrimers.
Nature, 623, 2023
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3LQA
 | | Crystal structure of clade C gp120 in complex with sCD4 and 21c Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, Heavy chain of anti HIV Fab from human 21c antibody, ... | | 著者 | Diskin, R, Marcovecchio, P.M, Bjorkman, P.J. | | 登録日 | 2010-02-08 | | 公開日 | 2010-04-07 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity.
Nat.Struct.Mol.Biol., 17, 2010
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7T0O
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