7T0O

cryoEM reconstruction of the HIV gp140 in complex with the extracellular domains of CD4 and the adnectin domain of Combinectin. The gp140 and CD4 coordinates from entry 6EDU were rigid body fitted to the EM map along withe the crystal structure of CD4+adnectin

Summary for 7T0O

• Entry DOI: 10.2210/pdb7t0o/pdb
• Related: 7T0R
• EMDB information: 25581
• Descriptor: BG505 SOSIP.664 gp140, T-cell surface glycoprotein CD4, Adnectin, ... (6 entities in total)
• Functional Keywords: inhibitor, hiv gp140, cd4, adnectin, antiviral protein
• Biological source: HIV-1 06TG.HT008; More
• Total number of polymer chains: 15
• Total formula weight: 397356.22

Authors

Concha, N.O.,William, S.P.,Wenzel, D.L. (deposition date: 2021-11-30, release date: 2022-01-12)

• Primary citation: Wensel, D.,Williams, S.,Dixon, D.P.,Ward, P.,McCormick, P.,Concha, N.,Stewart, E.,Hong, X.,Mazzucco, C.,Pal, S.,Ding, B.,Fellinger, C.,Krystal, M.; Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attachment.; J.Mol.Biol., 434:167395-167395, 2021; PubMed: 34896364; DOI: 10.1016/j.jmb.2021.167395

Experimental method

ELECTRON MICROSCOPY (8.7 Å)