7T0O

cryoEM reconstruction of the HIV gp140 in complex with the extracellular domains of CD4 and the adnectin domain of Combinectin. The gp140 and CD4 coordinates from entry 6EDU were rigid body fitted to the EM map along withe the crystal structure of CD4+adnectin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (D, G, I)	BG505 SOSIP.664 gp140	polymer	650	72830.4	3	Pfam (PF00516) Pfam (PF00517) UniProt (by SIFTS) (Q2N0S6)	HIV-1 06TG.HT008
2	D (B)	BG505 SOSIP.664 gp140	polymer	39	3337.1	1		HIV-1 06TG.HT008
3	E, F (F, J)	BG505 SOSIP.664 gp140	polymer	38	3252.0	2		HIV-1 06TG.HT008
4	G, I, K (H, L, M)	T-cell surface glycoprotein CD4	polymer	370	41385.4	3	UniProt (P01730) Pfam (PF00047) Pfam (PF05790) Pfam (PF09191)	Homo sapiens (human)	T-cell surface antigen T4/Leu-3
5	H, J, L (O, P, Q)	Adnectin	polymer	108	11959.2	3		Homo sapiens (human)
6	M, N, O (K, N, R)	BG505 SOSIP.664 gp140	polymer	35	2996.7	3		HIV-1 06TG.HT008

Sequence modifications

H, L, M: 1 - 364 (UniProt: P01730)

PDB	External Database	Details
His 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag
His 369	-	expression tag
His 370	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	397356.2
All*	Total formula weight	397356.2

*Water molecules are not included.