7T0R
Crystal structure of the anti-CD4 adnectin 6940_B01 as a complex with the extracellular domains of CD4 and ibalizumab fAb
Summary for 7T0R
Entry DOI | 10.2210/pdb7t0r/pdb |
Related | 7T0O |
Descriptor | Ibalizumab Light Chain, Ibalizumab Heavy Chain, T-cell surface glycoprotein CD4, ... (6 entities in total) |
Functional Keywords | inhibitor, hiv gp140, cd4, adnectin, ibalizumab, hiv env, combinectin, antiviral protein |
Biological source | Mus musculus (mouse) More |
Total number of polymer chains | 8 |
Total formula weight | 202565.76 |
Authors | Williams, S.P.,Concha, N.O.,Wensel, D.L.,Hong, X. (deposition date: 2021-11-30, release date: 2022-01-12, Last modification date: 2024-10-16) |
Primary citation | Wensel, D.,Williams, S.,Dixon, D.P.,Ward, P.,McCormick, P.,Concha, N.,Stewart, E.,Hong, X.,Mazzucco, C.,Pal, S.,Ding, B.,Fellinger, C.,Krystal, M. Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attachment. J.Mol.Biol., 434:167395-167395, 2021 Cited by PubMed: 34896364DOI: 10.1016/j.jmb.2021.167395 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.65 Å) |
Structure validation
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