7T0R

Crystal structure of the anti-CD4 adnectin 6940_B01 as a complex with the extracellular domains of CD4 and ibalizumab fAb

Summary for 7T0R

• Entry DOI: 10.2210/pdb7t0r/pdb
• Related: 7T0O
• Descriptor: Ibalizumab Light Chain, Ibalizumab Heavy Chain, T-cell surface glycoprotein CD4, ... (6 entities in total)
• Functional Keywords: inhibitor, hiv gp140, cd4, adnectin, ibalizumab, hiv env, combinectin, antiviral protein
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 8
• Total formula weight: 202565.76

Authors

Williams, S.P.,Concha, N.O.,Wensel, D.L.,Hong, X. (deposition date: 2021-11-30, release date: 2022-01-12, Last modification date: 2023-10-18)

• Primary citation: Wensel, D.,Williams, S.,Dixon, D.P.,Ward, P.,McCormick, P.,Concha, N.,Stewart, E.,Hong, X.,Mazzucco, C.,Pal, S.,Ding, B.,Fellinger, C.,Krystal, M.; Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attachment.; J.Mol.Biol., 434:167395-167395, 2021; PubMed: 34896364; DOI: 10.1016/j.jmb.2021.167395

Experimental method

X-RAY DIFFRACTION (3.65 Å)