7T0R

Crystal structure of the anti-CD4 adnectin 6940_B01 as a complex with the extracellular domains of CD4 and ibalizumab fAb

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (L, B)	Ibalizumab Light Chain	polymer	219	24245.9	2		Mus musculus (mouse)
2	B, E (H, C)	Ibalizumab Heavy Chain	polymer	229	24785.5	2		Mus musculus (mouse)
3	C, F (A, D)	T-cell surface glycoprotein CD4	polymer	373	41667.7	2	UniProt (P01730) Pfam (PF00047) Pfam (PF05790) Pfam (PF09191)	Homo sapiens (human)	T-cell surface antigen T4/Leu-3
4	G, H (G, I)	Adnectin 6940_B01	polymer	94	10314.5	2		synthetic construct
5	I, K (A, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6	J (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)

Sequence modifications

A, D: 1 - 364 (UniProt: P01730)

PDB	External Database	Details
Gly 365	-	expression tag
Ser 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag
His 369	-	expression tag
His 370	-	expression tag
His 371	-	expression tag
His 372	-	expression tag
His 373	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	202027.3
Non-Polymers*	Number of molecules	3
	Total formula weight	538.5
All*	Total formula weight	202565.8

*Water molecules are not included.