7T0R
Crystal structure of the anti-CD4 adnectin 6940_B01 as a complex with the extracellular domains of CD4 and ibalizumab fAb
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | L, B | Ibalizumab Light Chain | polymer | 219 | 24245.9 | 2 | Mus musculus (mouse) | ||
2 | H, C | Ibalizumab Heavy Chain | polymer | 229 | 24785.5 | 2 | Mus musculus (mouse) | ||
3 | A, D | T-cell surface glycoprotein CD4 | polymer | 373 | 41667.7 | 2 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) Pfam (PF09191) In PDB | Homo sapiens (human) | T-cell surface antigen T4/Leu-3 |
4 | G, I | Adnectin 6940_B01 | polymer | 94 | 10314.5 | 2 | synthetic construct | ||
5 | A, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
6 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
A, D: 1 - 364 (UniProt: P01730)
PDB | External Database | Details |
---|---|---|
Gly 365 | - | expression tag |
Ser 366 | - | expression tag |
His 367 | - | expression tag |
His 368 | - | expression tag |
His 369 | - | expression tag |
His 370 | - | expression tag |
His 371 | - | expression tag |
His 372 | - | expression tag |
His 373 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 202027.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 538.5 | |
All* | Total formula weight | 202565.8 |