7LA4
| Integrin AlphaIIbBeta3-PT25-2 Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Bush, M.W, Walz, T, Coller, B, Filizola, M, Spasic, A, Nesic, D, Li, J. | 登録日 | 2021-01-05 | 公開日 | 2022-01-12 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin alpha IIb beta 3 for ligand binding. Blood Adv, 5, 2021
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1M1X
| CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+ | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Xiong, J.-P, Stehle, T, Zhang, R, Joachimiak, A, Frech, M, Goodman, S.L, Arnaout, M.A. | 登録日 | 2002-06-20 | 公開日 | 2002-08-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science, 296, 2002
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4MMX
| Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... | 著者 | van Agthoven, J, Xiong, J, Arnaout, M.A. | 登録日 | 2013-09-09 | 公開日 | 2014-03-26 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | 主引用文献 | Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin. Nat.Struct.Mol.Biol., 21, 2014
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8T2V
| Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | 登録日 | 2023-06-06 | 公開日 | 2023-07-26 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids. Nat Commun, 14, 2023
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4O02
| AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment. | 分子名称: | 17E6 heavy chain, 17E6 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mahalingam, B, van Agthoven, J, Xiong, J, Arnaout, M.A. | 登録日 | 2013-12-13 | 公開日 | 2014-04-02 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.605 Å) | 主引用文献 | Atomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex. J.Biol.Chem., 289, 2014
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4CAK
| Three-dimensional reconstruction of intact human integrin alphaIIbbeta3 in a phospholipid bilayer nanodisc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-IIb, ... | 著者 | Choi, W.S, Rice, W.J, Stokes, D.L, Coller, B.S. | 登録日 | 2013-10-08 | 公開日 | 2013-10-30 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (20.5 Å) | 主引用文献 | Three-Dimensional Reconstruction of Intact Human Integrin Alphaiibbeta3; New Implications for Activation-Dependent Ligand Binding. Blood, 122, 2013
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6AVQ
| The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance | 分子名称: | Integrin alpha-V, Integrin beta-3, LM609 Fab heavy chain, ... | 著者 | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | 登録日 | 2017-09-04 | 公開日 | 2017-11-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (35 Å) | 主引用文献 | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance. Structure, 25, 2017
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6AVR
| Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609 | 分子名称: | Fab LM609 heavy chain, Fab LM609 light chain, Integrin alpha-V, ... | 著者 | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | 登録日 | 2017-09-04 | 公開日 | 2017-11-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (35 Å) | 主引用文献 | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance. Structure, 25, 2017
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6AVU
| Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609 | 分子名称: | Fab LM609 heavy chain, Fab LM609 light chain, Integrin alpha-V, ... | 著者 | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | 登録日 | 2017-09-04 | 公開日 | 2017-11-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (35 Å) | 主引用文献 | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance. Structure, 25, 2017
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2LJE
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2L1C
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2KNC
| Platelet integrin ALFAIIB-BETA3 transmembrane-cytoplasmic heterocomplex | 分子名称: | Integrin alpha-IIb, Integrin beta-3 | 著者 | Yang, J, Ma, Y, Page, R.C, Misra, S, Plow, E.F, Qin, J. | 登録日 | 2009-08-20 | 公開日 | 2009-09-29 | 最終更新日 | 2024-05-08 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of an integrin alphaIIb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation. Proc.Natl.Acad.Sci.USA, 106, 2009
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2H7E
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2LJD
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2LJF
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2KV9
| Integrin beta3 subunit in a disulfide linked alphaIIb-beta3 cytosolic domain | 分子名称: | Integrin beta-3 | 著者 | Metcalf, D.G, Kielec, J.M, Valentine, K.G, Wand, A, Bennett, J.S, William, D.F, Moore, D.T, Molnar, K. | 登録日 | 2010-03-10 | 公開日 | 2011-01-12 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR analysis of the {alpha}IIb{beta}3 cytoplasmic interaction suggests a mechanism for integrin regulation. Proc.Natl.Acad.Sci.USA, 107, 2010
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2L91
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2RMZ
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2RN0
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1S4X
| NMR Structure of the integrin B3 cytoplasmic domain in DPC micelles | 分子名称: | Integrin beta-3 | 著者 | Vinogradova, O, Vaynberg, J, Kong, X, Haas, T.A, Plow, E.F, Qin, J. | 登録日 | 2004-01-19 | 公開日 | 2004-03-09 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Membrane-mediated structural transitions at the cytoplasmic face during integrin activation. Proc.Natl.Acad.Sci.USA, 101, 2004
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2H7D
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1KUZ
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1KUP
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7KN0
| Structure of the integrin aIIb(W968V)b3 transmembrane complex | 分子名称: | Integrin alpha-IIb, Integrin beta-3 | 著者 | Situ, A.J, Kim, J, An, W, Kim, C, Ulmer, T.S. | 登録日 | 2020-11-03 | 公開日 | 2021-09-15 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Insight Into Pathological Integrin alpha IIb beta 3 Activation From Safeguarding The Inactive State. J.Mol.Biol., 433, 2021
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1M8O
| Platelet integrin alfaIIb-beta3 cytoplasmic domain | 分子名称: | platelet integrin alfaIIb subunit: cytoplasmic domain, platelet integrin beta3 subunit: cytoplasmic domain | 著者 | Vinogradova, O, Velyvis, A, Velyviene, A, Hu, B, Haas, T, Plow, E.F, Qin, J. | 登録日 | 2002-07-25 | 公開日 | 2002-09-18 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | A Structural mechanism of integrin alfaiib beta3
"Inside-out" Activation as regulated by its cytoplasmic face. Cell(Cambridge,Mass.), 110, 2002
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