Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide

Summary for 2H7D

DescriptorTalin-1, Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (2 entities in total)
Functional Keywordsprotein-peptide complex, alpha helix, beta sheet, structural protein
Biological sourceGallus gallus (chicken)
Cellular locationCell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side P54939
Endomembrane system O70161
Total number of polymer chains2
Total molecular weight15755.15
Wegener, K.L. (deposition date: 2006-06-02, release date: 2007-01-30, Last modification date: 2011-07-13)
Primary citation
Wegener, K.L.,Partridge, A.W.,Han, J.,Pickford, A.R.,Liddington, R.C.,Ginsberg, M.H.,Campbell, I.D.
Structural basis of integrin activation by talin
CELL(CAMBRIDGE,MASS.), 128:171-182, 2007
PubMed: 17218263 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2006.10.048
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers00.1%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 2h7d
no rotation
Molmil generated image of 2h7d
rotated about x axis by 90°
Molmil generated image of 2h7d
rotated about y axis by 90°