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PDB: 354 件
4EX0
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BU of 4ex0 by Molmil
Human Insulin
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R.
登録日2012-04-29
公開日2013-05-01
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structural meta-analysis of regular human insulin in pharmaceutical formulations.
Eur J Pharm Biopharm, 85, 2013
4GBN
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BU of 4gbn by Molmil
Crystal structure of aspart insulin at pH 6.5
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Lima, L.M.T.R, Favero-Retto, M.P, Palmieri, L.C.
登録日2012-07-27
公開日2013-06-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.872 Å)
主引用文献A T3R3 hexamer of the human insulin variant B28Asp.
Biophys.Chem., 173, 2013
5MT9
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BU of 5mt9 by Molmil
Human insulin in complex with serotonin and arginine
分子名称: ARGININE, CHLORIDE ION, Insulin, ...
著者Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L.
登録日2017-01-07
公開日2017-04-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292, 2017
8ONR
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BU of 8onr by Molmil
Crystal structure of human insulin trans-HypB26-DTI analogue
分子名称: Insulin A chain, Insulin B chain, PHENOL, ...
著者Brzozowski, A.M, Zakova, L, Jiracek, J.
登録日2023-04-03
公開日2024-04-10
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Crystal structure of human insulin trans-HypB26-DTI analogue
To Be Published
4Z76
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BU of 4z76 by Molmil
Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ...
著者Rizkallah, P.J, Cole, D.K.
登録日2015-04-06
公開日2015-06-24
最終更新日2015-08-12
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide.
J.Biol.Chem., 290, 2015
1EV6
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BU of 1ev6 by Molmil
Structure of the monoclinic form of the M-cresol/insulin R6 hexamer
分子名称: CHLORIDE ION, INSULIN, M-CRESOL, ...
著者Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H.
登録日2000-04-19
公開日2000-12-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献R6 Hexameric Insulin Complexed with m-Cresol or Resorcinol
Biochem.Biophys.Res.Commun., 56, 2000
3ILG
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BU of 3ilg by Molmil
Crystal structure of humnan insulin Sr+2 complex
分子名称: Insulin A chain, Insulin B chain, STRONTIUM ION
著者Raghavendra, N, Pattabhi, V, Rajan, S.S.
登録日2009-08-07
公開日2010-08-11
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Metal induced conformational changes in human insulin: Crystal structures of Sr+2, Ni+2 and Cu+2 complexes of human insulin
To be Published
1EVR
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BU of 1evr by Molmil
The structure of the resorcinol/insulin R6 hexamer
分子名称: CHLORIDE ION, INSULIN, RESORCINOL, ...
著者Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H.
登録日2000-04-20
公開日2000-12-04
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献R6 hexameric insulin complexed with m-cresol or resorcinol.
Acta Crystallogr.,Sect.D, 56, 2000
5BPO
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Human insulin with intra-chain chemical crosslink between modified B27 and B29
分子名称: Insulin
著者Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L.
登録日2015-05-28
公開日2016-02-03
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6, 2016
1TYL
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THE STRUCTURE OF A COMPLEX OF HEXAMERIC INSULIN AND 4'-HYDROXYACETANILIDE
分子名称: CHLORIDE ION, INSULIN, N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL), ...
著者Smith, G.D, Ciszak, E.
登録日1994-06-21
公開日1994-09-30
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The structure of a complex of hexameric insulin and 4'-hydroxyacetanilide.
Proc.Natl.Acad.Sci.USA, 91, 1994
1TYM
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THE STRUCTURE OF A COMPLEX OF HEXAMERIC INSULIN AND 4'-HYDROXYACETANILIDE
分子名称: CHLORIDE ION, INSULIN, N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL), ...
著者Smith, G.D, Ciszak, E.
登録日1994-06-21
公開日1994-09-30
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The structure of a complex of hexameric insulin and 4'-hydroxyacetanilide.
Proc.Natl.Acad.Sci.USA, 91, 1994
3KQ6
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BU of 3kq6 by Molmil
Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A.
登録日2009-11-17
公開日2010-02-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
2WS4
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BU of 2ws4 by Molmil
Semi-synthetic analogue of human insulin ProB26-DTI in monomer form
分子名称: INSULIN A CHAIN, INSULIN B CHAIN
著者Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
登録日2009-09-03
公開日2010-02-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
1HTV
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BU of 1htv by Molmil
CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN
分子名称: INSULIN, ZINC ION
著者Ye, J, Chang, W, Liang, D.
登録日2001-01-01
公開日2001-05-23
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of destripeptide (B28-B30) insulin: implications for insulin dissociation.
Biochim.Biophys.Acta, 1547, 2001
3ZQR
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BU of 3zqr by Molmil
NMePheB25 insulin analogue crystal structure
分子名称: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ...
著者Antolikova, E, Zakova, L, Turkenburg, J.P, Watson, C.J, Hanclova, I, Sanda, M, Cooper, A, Kraus, T, Brzozowski, A.M, Jiracek, J.A.
登録日2011-06-10
公開日2011-08-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Non-Equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface.
J.Biol.Chem., 286, 2011
5CO9
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Crystal structure of human zinc insulin at pH 6.5
分子名称: CHLORIDE ION, Insulin, ZINC ION
著者Lima, L.M.T.R, Palmieri, L.C.
登録日2015-07-20
公開日2015-08-26
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Crystal structure of human zinc insulin at pH 6.5
To Be Published
7JP3
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BU of 7jp3 by Molmil
Des-B29,B30-insulin
分子名称: CHLORIDE ION, Insulin B chain,Insulin A chain, PHENOL, ...
著者Yoder, J, Weiss, M.A, DiMarchi, R, Zaykov, A.
登録日2020-08-07
公開日2021-10-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Des-B29,B30-insulin
To Be Published
2C8Q
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BU of 2c8q by Molmil
insuline(1sec) and UV laser excited fluorescence
分子名称: INSULIN A CHAIN, INSULIN B CHAIN
著者Vernede, X, Lavault, B, Ohana, J, Nurizzo, D, Joly, J, Jacquamet, L, Felisaz, F, Cipriani, F, Bourgeois, D.
登録日2005-12-06
公開日2006-03-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Uv Laser-Excited Fluorescence as a Tool for the Visualization of Protein Crystals Mounted in Loops.
Acta Crystallogr.,Sect.D, 62, 2006
1OS3
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BU of 1os3 by Molmil
Dehydrated T6 human insulin at 100 K
分子名称: CHLORIDE ION, Insulin, ZINC ION
著者Smith, G.D, Blessing, R.H.
登録日2003-03-18
公開日2003-07-29
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Lessons from an aged, dried crystal of T(6) human insulin.
Acta Crystallogr.,Sect.D, 59, 2003
3ZS2
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BU of 3zs2 by Molmil
TyrB25,NMePheB26,LysB28,ProB29-insulin analogue crystal structure
分子名称: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ...
著者Antolikova, E, Zakova, L, Turkenburg, J.P, Watson, C.J, Hanclova, I, Sanda, M, Cooper, A, Kraus, T, Brzozowski, A.M, Jiracek, J.A.
登録日2011-06-21
公開日2011-08-31
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Non-Equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface.
J.Biol.Chem., 286, 2011
2OM1
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BU of 2om1 by Molmil
Structure of human insulin in presence of thiocyanate at pH 6.5
分子名称: GLYCEROL, Insulin A chain, Insulin B chain, ...
著者Norrman, M, Schluckebier, G.
登録日2007-01-20
公開日2007-12-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH.
Bmc Struct.Biol., 7, 2007
5UU4
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BU of 5uu4 by Molmil
Insulin with proline analog ThioP at position B28 in the R6 state
分子名称: CHLORIDE ION, Insulin A Chain, Insulin B Chain, ...
著者Lieblich, S.A, Fang, K.Y, Tirrell, D.A.
登録日2017-02-16
公開日2018-02-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.973 Å)
主引用文献Insulin with proline analog ThioP at position B28 in the R6 state
To Be Published
4EFX
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BU of 4efx by Molmil
Highly biologically active insulin with additional disulfide bond
分子名称: Insulin, ZINC ION
著者Norrman, M, Vinther, T.N.
登録日2012-03-30
公開日2013-03-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Insulin analog with additional disulfide bond has increased stability and preserved activity.
Protein Sci., 22, 2013
3U4N
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A novel covalently linked insulin dimer
分子名称: Insulin A chain, Insulin B chain
著者Norrman, M, Vinther, T.N.
登録日2011-10-10
公開日2012-04-11
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization.
Plos One, 7, 2012
1J73
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Crystal structure of an unstable insulin analog with native activity.
分子名称: ZINC ION, insulin a, insulin b
著者Wan, Z, Zhao, M, Nakagawa, S, Jia, W, Weiss, M.A.
登録日2001-05-15
公開日2001-05-30
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002

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