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PDB: 467 件
8UF7
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BU of 8uf7 by Molmil
Cryo-EM structure of POmAb, a Type-I anti-prothrombin antiphospholipid antibody, bound to kringle-1 of human prothrombin
分子名称: POmAb Heavy Chain, POmAb Light Chain, Prothrombin
著者Kumar, S, Summers, B, Basore, K, Pozzi, N.
登録日2023-10-03
公開日2024-02-14
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structure and functional basis of prothrombin recognition by a type I antiprothrombin antiphospholipid antibody.
Blood, 143, 2024
5EDK
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BU of 5edk by Molmil
Crystal structure of prothrombin deletion mutant residues 146-167 ( Form II ).
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ...
著者Pozzi, N, Chen, Z, Di Cera, E.
登録日2015-10-21
公開日2016-01-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.214 Å)
主引用文献How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin.
J.Biol.Chem., 291, 2016
6P9U
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BU of 6p9u by Molmil
Crystal structure of human thrombin mutant W215A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin, ZINC ION
著者Pelc, L.A, Koester, S.K, Chen, Z, Di Cera, E.
登録日2019-06-10
公開日2019-09-04
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin.
Sci Rep, 9, 2019
2HPP
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BU of 2hpp by Molmil
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin
分子名称: ALPHA-THROMBIN HEAVY CHAIN, ALPHA-THROMBIN LIGHT CHAIN, D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, ...
著者Tulinsky, A, Padmanabhan, K.
登録日1993-04-28
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin.
Biochemistry, 32, 1993
2HPQ
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BU of 2hpq by Molmil
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, ...
著者Tulinsky, A, Padmanabhan, K.
登録日1993-04-28
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin.
Biochemistry, 32, 1993
4HZH
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BU of 4hzh by Molmil
Structure of recombinant Gla-domainless prothrombin mutant S525A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin
著者Pozzi, N, Niu, W, Gohara, D.W, Chen, Z, Di Cera, E.
登録日2012-11-15
公開日2013-06-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation.
J.Biol.Chem., 288, 2013
4O03
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BU of 4o03 by Molmil
Crystal structure of Ca2+ bound prothrombin deletion mutant residues 146-167
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Prothrombin
著者Pozzi, N, Chen, Z, Shropshire, D.B, Pelc, L.A, Di Cera, E.
登録日2013-12-13
公開日2014-05-21
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (3.38 Å)
主引用文献The linker connecting the two kringles plays a key role in prothrombin activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
1NRQ
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BU of 1nrq by Molmil
CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), RECEPTOR BASED PEPTIDE D-FPR'S
著者Tulinsky, A, Mathews, I.I.
登録日1994-01-18
公開日1994-05-31
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Biochemistry, 33, 1994
5EW2
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BU of 5ew2 by Molmil
Human thrombin sandwiched between two DNA aptamers: HD22 and HD1-deltaT12
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, HD1-deltaT12, ...
著者Pica, A, Russo Krauss, I, Parente, V, Sica, F.
登録日2015-11-20
公開日2016-11-30
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.59 Å)
主引用文献Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers.
Nucleic Acids Res., 45, 2017
2A45
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BU of 2a45 by Molmil
Crystal structure of the complex between thrombin and the central "E" region of fibrin
分子名称: D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Fibrinogen alpha chain, Fibrinogen beta chain, ...
著者Pechik, I, Madrazo, J, Gilliland, G.L, Medved, L.
登録日2005-06-27
公開日2006-05-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.65 Å)
主引用文献Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly.
Biochemistry, 45, 2006
7TPP
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BU of 7tpp by Molmil
Cryo-em structure of human prothrombin:prothrombinase at 4.1 Angstrom resolution
分子名称: Activated factor Xa heavy chain, Coagulation factor Va, Factor X light chain, ...
著者Di Cera, E, Ruben, E.A.
登録日2022-01-25
公開日2022-05-04
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Cryo-EM structure of the prothrombin-prothrombinase complex.
Blood, 139, 2022
6C2W
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Crystal structure of human prothrombin mutant S101C/A470C
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ...
著者Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N.
登録日2018-01-09
公開日2018-02-28
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (4.12 Å)
主引用文献Structure of prothrombin in the closed form reveals new details on the mechanism of activation.
Sci Rep, 8, 2018
6BJR
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BU of 6bjr by Molmil
Crystal structure of prothrombin mutant S101C/A470C
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ...
著者Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N.
登録日2017-11-06
公開日2018-06-27
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (6 Å)
主引用文献Structure of prothrombin in the closed form reveals new details on the mechanism of activation.
Sci Rep, 8, 2018
9CTH
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BU of 9cth by Molmil
Preliminary map of the Prothrombin-prothrombinase complex on nano discs
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated Factor V (FVa) heavy chain, Activated Factor V (FVa) light chain, ...
著者Stojanovski, B.M, Mohammed, B.M, Di Cera, E.
登録日2024-07-25
公開日2024-08-07
最終更新日2024-08-14
実験手法ELECTRON MICROSCOPY (6.47 Å)
主引用文献The Prothrombin-Prothrombinase Interaction.
Subcell Biochem, 104, 2024
5Z5W
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BU of 5z5w by Molmil
VFR12 in complex with LPS micelles
分子名称: Peptide from Prothrombin
著者Saravanan, R, Schmidtchen, A.
登録日2018-01-21
公開日2018-03-07
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides.
Nat Commun, 9, 2018
8BWW
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BU of 8bww by Molmil
Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs
分子名称: Thrombin light chain
著者Diehl, C.
登録日2022-12-07
公開日2023-09-06
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs.
Nat Commun, 14, 2023
5Z5X
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BU of 5z5x by Molmil
HVF18 in complex with LPS micelles
分子名称: Peptide from Prothrombin
著者Saravanan, R, Schmidtchen, A.
登録日2018-01-21
公開日2018-03-07
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides.
Nat Commun, 9, 2018

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