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PDB: 137 件

7A34
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Intertwined dimer of the c-Src SH3 domain mutant V111L-N113S-T114S
分子名称: DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, TRIETHYLENE GLYCOL
著者Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C.
登録日2020-08-18
公開日2021-08-25
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Intertwined dimer of the c-Src SH3 domain mutant V111L-N113S-T114S
To be published
4JZ3
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Crystal structure of the chicken c-Src-SH3 domain intertwined dimer
分子名称: DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, TRIETHYLENE GLYCOL
著者Camara-Artigas, A.
登録日2013-04-02
公開日2014-04-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Electrostatic Effects in the Folding of the SH3 Domain of the c-Src Tyrosine Kinase: pH-Dependence in 3D-Domain Swapping and Amyloid Formation.
Plos One, 9, 2014
3U4W
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Src in complex with DNA-templated macrocyclic inhibitor MC4b
分子名称: GLYCEROL, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION, ...
著者Seeliger, M.A, Liu, D.R, Georghiou, G, Kleiner, R.E, Pulkoski-Gross, M.
登録日2011-10-10
公開日2012-02-22
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.
Nat.Chem.Biol., 8, 2012
4OMM
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Crystal structure of the intertwined dimer of the c-Src tyrosine kinase SH3 domain mutant N113S
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Proto-oncogene tyrosine-protein kinase Src, ...
著者Camara-Artigas, A, Bacarizo, J.
登録日2014-01-27
公開日2015-01-28
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The role of Gutamine 128 of the SH3 domain of the c-Src tyrosine kinase in 3D domain swapping and amyloid formation
To be Published
6HVE
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Kinase domain of cSrc in complex with compound 9
分子名称: Proto-oncogene tyrosine-protein kinase Src, ~{N}-[3-(4-methoxy-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]prop-2-enamide
著者Keul, M, Mueller, M.P, Rauh, D.
登録日2018-10-10
公開日2019-10-23
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.
Chem Sci, 10, 2019
7A3B
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Intertwined dimer of the c-Src SH3 domain mutant E106D
分子名称: GLYCEROL, Proto-oncogene tyrosine-protein kinase Src, TRIETHYLENE GLYCOL
著者Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C.
登録日2020-08-18
公開日2021-08-25
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Intertwined dimer of the c-Src SH3 domain mutant E106D
To be published
7AH3
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Kinase domain of cSrc in complex with a pyrazolopyrimidine
分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Dello Iacono, L, Kleinboelting, S, Fallacara, A.L, Rauh, D.
登録日2020-09-24
公開日2021-10-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Insights into the binding of pyrazolopyrimidines to Src kinase
To Be Published
5I11
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Crystal structure of the intertwined form of the Src tyrosine kinase SH3 domain T114S-Q128R mutant
分子名称: ACETATE ION, DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, ...
著者Camara-Artigas, A.
登録日2016-02-05
公開日2016-03-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of the intertwined form of the Src tyrosine kinase SH3 domain T114S-Q128R mutant
To Be Published
7PVZ
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Crystal structure of the intertwined dimer of the c-Src SH3 domain E93V-S94A-R95S-T96G mutant
分子名称: Isoform 2 of Proto-oncogene tyrosine-protein kinase Src
著者Camara-Artigas, A, Salinas Garcia, M.C.
登録日2021-10-05
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The effect of the hinge loops composition in the domain swapping of the SH3 domain
To be published
4OMQ
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BU of 4omq by Molmil
Crystal structure of the intertwined dimer of the c-Src tyrosine kinase SH3 domain mutant S94A
分子名称: DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION, ...
著者Camara-Artigas, A, Bacarizo, J.
登録日2014-01-27
公開日2015-01-28
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The role of Gutamine 128 of the SH3 domain of the c-Src tyrosine kinase in 3D domain swapping and amyloid formation
To be Published
4OMP
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BU of 4omp by Molmil
Crystal structure of the intertwined dimer of the c-Src tyrosine kinase SH3 domain mutant Q128K
分子名称: DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, TRIETHYLENE GLYCOL
著者Camara-Artigas, A, Bacarizo, J.
登録日2014-01-27
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Electrostatic Effects in the Folding of the SH3 Domain of the c-Src Tyrosine Kinase: pH-Dependence in 3D-Domain Swapping and Amyloid Formation.
Plos One, 9, 2014
5XP7
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BU of 5xp7 by Molmil
C-Src in complex with ATP-CHCl
分子名称: GLYCEROL, MAGNESIUM ION, Proto-oncogene tyrosine-protein kinase Src, ...
著者Guo, M, Dai, S, Duan, Y, Chen, L, Chen, Y.
登録日2017-06-01
公開日2017-09-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.012 Å)
主引用文献Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
3DQW
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c-Src kinase domain Thr338Ile mutant in complex with ATPgS
分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Proto-oncogene tyrosine-protein kinase Src
著者Azam, M, Seeliger, M.A, Gray, N, Kuriyan, J, Daley, G.Q.
登録日2008-07-09
公開日2008-09-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.017 Å)
主引用文献Activation of tyrosine kinases by mutation of the gatekeeper threonine.
Nat.Struct.Mol.Biol., 15, 2008
2OIQ
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Crystal Structure of chicken c-Src kinase domain in complex with the cancer drug imatinib.
分子名称: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, GLYCEROL, Proto-oncogene tyrosine-protein kinase Src
著者Seeliger, M.A, Nagar, B, Frank, F, Cao, X, Henderson, M.N, Kuriyan, J.
登録日2007-01-11
公開日2007-03-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty.
Structure, 15, 2007
1F1W
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BU of 1f1w by Molmil
SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN
分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, S(PTR)VNVQN PHOSPHOPEPTIDE
著者Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F.
登録日2000-05-20
公開日2000-07-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for specificity switching of the Src SH2 domain.
Mol.Cell, 5, 2000
4O2P
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Kinase domain of cSrc in complex with a substituted pyrazolopyrimidine
分子名称: 1-[(2R)-2-chloro-2-phenylethyl]-6-{[2-(morpholin-4-yl)ethyl]sulfanyl}-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
著者Richters, A, Rauh, D.
登録日2013-12-17
公開日2015-03-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma.
J.Med.Chem., 58, 2015
6HVF
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BU of 6hvf by Molmil
Kinase domain of cSrc in complex with compound 29B
分子名称: 1,2-ETHANEDIOL, Proto-oncogene tyrosine-protein kinase Src, ~{N}-[3-[3-ethyl-6-[4-(4-methylpiperazin-1-yl)phenyl]-4-oxidanylidene-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]prop-2-enamide
著者Keul, M, Mueller, M.P, Rauh, D.
登録日2018-10-10
公開日2019-10-23
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.
Chem Sci, 10, 2019
5XP5
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C-Src in complex with ATP-Chf
分子名称: MAGNESIUM ION, Proto-oncogene tyrosine-protein kinase Src, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[(S)-fluoranyl-[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid
著者Duan, Y, Guo, M, Dai, S, Chen, L, Chen, Y.
登録日2017-06-01
公開日2018-02-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.101 Å)
主引用文献Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
7D57
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C-Src in complex with FIIN-2
分子名称: N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION
著者Chen, Y.H, Qu, L.Z.
登録日2020-09-25
公開日2021-10-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.104 Å)
主引用文献Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors
Commun Chem, 5, 2022
5J5S
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Src kinase in complex with a sulfonamide inhibitor
分子名称: N-{4-[8-amino-3-(propan-2-yl)imidazo[1,5-a]pyrazin-1-yl]naphthalen-1-yl}-N'-[3-(trifluoromethyl)phenyl]urea, Proto-oncogene tyrosine-protein kinase Src
著者Lebedev, I, Feldman, H.C, Georghiou, G, Maly, D.J, Seeliger, M.
登録日2016-04-03
公開日2016-06-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.153 Å)
主引用文献Structural and Functional Analysis of the Allosteric Modulation of IRE1a with ATP-Competitive Kinase Inhibitors
To Be Published
3G5D
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Kinase domain of cSrc in complex with Dasatinib
分子名称: GLYCEROL, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Proto-oncogene tyrosine-protein kinase Src
著者Grutter, C, Kluter, S, Rauh, D.
登録日2009-02-05
公開日2009-06-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc
J.Med.Chem., 52, 2009
3GEQ
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Structural basis for the chemical rescue of Src kinase activity
分子名称: 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Proto-oncogene tyrosine-protein kinase Src
著者Muratore, K.E, Seeliger, M.A, Wang, Z, Fomina, D, Neiswinger, J, Havranek, J.J, Baker, D, Kuriyan, J, Cole, P.A.
登録日2009-02-25
公開日2009-04-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Comparative analysis of mutant tyrosine kinase chemical rescue.
Biochemistry, 48, 2009
7A3D
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Intertwined dimer of the c-Src SH3 domain mutant T125S
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Proto-oncogene tyrosine-protein kinase Src, ...
著者Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C.
登録日2020-08-18
公開日2021-08-25
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Intertwined dimer of the c-Src SH3 domain mutant T125S
To be published
3UQG
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c-SRC kinase domain in complex with bumpless BKI analog UW1243
分子名称: 1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
著者Merritt, E.A, Larson, E.T.
登録日2011-11-20
公開日2012-03-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1.
J.Med.Chem., 55, 2012
3SVV
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Crystal Structure of T338C c-Src covalently bound to vinylsulfonamide-pyrazolopyrimidine 9
分子名称: N-(3-{[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl}phenyl)ethanesulfonamide, Proto-oncogene tyrosine-protein kinase Src
著者Garske, A.L, Peters, U, Cortesi, A, Perez, J, Shokat, K.M.
登録日2011-07-12
公開日2011-08-17
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.204 Å)
主引用文献Chemical genetic strategy for targeting protein kinases based on covalent complementarity.
Proc.Natl.Acad.Sci.USA, 108, 2011

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