3G5D

Kinase domain of cSrc in complex with Dasatinib

Summary for 3G5D

• Entry DOI: 10.2210/pdb3g5d/pdb
• Related: 3F3T 3F3U 3F3V 3F3W
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, GLYCEROL, ... (4 entities in total)
• Functional Keywords: type ii, dfg-out, tyrosine-protein kinase, dasatinib, atp-binding, kinase, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase
• Biological source: Gallus gallus (chicken)
• Cellular location: Cell membrane (By similarity): P00523
• Total number of polymer chains: 2
• Total formula weight: 66645.62

Authors

Grutter, C.,Kluter, S.,Rauh, D. (deposition date: 2009-02-05, release date: 2009-06-02, Last modification date: 2023-11-01)

• Primary citation: Getlik, M.,Grutter, C.,Simard, J.R.,Kluter, S.,Rabiller, M.,Rode, H.B.,Robubi, A.,Rauh, D.; Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc; J.Med.Chem., 52:3915-3926, 2009; PubMed: 19462975; DOI: 10.1021/jm9002928

Experimental method

X-RAY DIFFRACTION (2.2 Å)