3F3W

Drug resistant cSrc kinase domain in complex with inhibitor RL45 (Type II)

Summary for 3F3W

Entry DOI	10.2210/pdb3f3w/pdb
Related	2QI8 2QLQ 2QQ7 3F3T 3F3U 3F3V
Descriptor	Proto-oncogene tyrosine-protein kinase Src, 1-{4-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea (3 entities in total)
Functional Keywords	allosteric, type ii, dfg-out, drug resistance mutation, alternative splicing, atp-binding, kinase, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
Biological source	Gallus gallus (Chicken)
Cellular location	Cell membrane (By similarity): P00523
Total number of polymer chains	2
Total formula weight	66558.81
Authors	Grutter, C.,Kluter, S.,Getlik, M.,Rauh, D. (deposition date: 2008-10-31, release date: 2009-06-02, Last modification date: 2023-11-01)
Primary citation	Getlik, M.,Grutter, C.,Simard, J.R.,Kluter, S.,Rabiller, M.,Rode, H.B.,Robubi, A.,Rauh, D. Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc J.Med.Chem., 52:3915-3926, 2009 Cited by PubMed: 19462975 DOI: 10.1021/jm9002928 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation