3F3W
Drug resistant cSrc kinase domain in complex with inhibitor RL45 (Type II)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32772.8 | 2 | UniProt (P00523) Pfam (PF07714) | Gallus gallus (Chicken) | pp60c-src, p60-Src, c-Src |
| 2 | C, D (A, B) | 1-{4-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea | non-polymer | 506.6 | 2 | Chemie (1BU) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | expression tag |
| His 249 | - | expression tag |
| Met 250 | - | expression tag |
| Met 338 | Thr 338 | engineered mutation |
| Cys 345 | Ser 345 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65545.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1013.2 | |
| All* | Total formula weight | 66558.8 |
