2QLQ

Crystal structure of SRC kinase domain with covalent inhibitor RL3

Summary for 2QLQ

Entry DOI	10.2210/pdb2qlq/pdb
Related	2HWP 2QI8 2QIG 2QQ7
Descriptor	Proto-oncogene tyrosine-protein kinase Src, (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide (3 entities in total)
Functional Keywords	src kinase domain, drug resistance, irreversible inhibitor, kovalent inhibitor, alternative splicing, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphorylation, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
Biological source	Gallus gallus (chicken)
Cellular location	Cell membrane (By similarity): P00523
Total number of polymer chains	2
Total formula weight	66764.35
Authors	Michalczyk, A.,Rode, H.B.,Gruetter, C.,Rauh, D. (deposition date: 2007-07-13, release date: 2008-03-11, Last modification date: 2021-10-20)
Primary citation	Michalczyk, A.,Kluter, S.,Rode, H.B.,Simard, J.R.,Grutter, C.,Rabiller, M.,Rauh, D. Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg.Med.Chem., 16:3482-3488, 2008 Cited by PubMed: 18316192 DOI: 10.1016/j.bmc.2008.02.053 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation