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2QI8

Crystal structure of drug resistant SRC kinase domain

Summary for 2QI8
Entry DOI10.2210/pdb2qi8/pdb
DescriptorProto-oncogene tyrosine-protein kinase Src, GLYCEROL (3 entities in total)
Functional Keywordssrc kinase domain; drug resistance, signaling protein, transferase
Biological sourceGallus gallus (chicken)
Cellular locationCell membrane (By similarity): P00523
Total number of polymer chains2
Total formula weight65637.70
Authors
Michalczyk, A.,Rode, H.B.,Gruetter, C.,Rauh, D. (deposition date: 2007-07-03, release date: 2008-03-18, Last modification date: 2024-02-21)
Primary citationMichalczyk, A.,Kluter, S.,Rode, H.B.,Simard, J.R.,Grutter, C.,Rabiller, M.,Rauh, D.
Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR.
Bioorg.Med.Chem., 16:3482-3488, 2008
Cited by
PubMed: 18316192
DOI: 10.1016/j.bmc.2008.02.053
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.32 Å)
Structure validation

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