2QI8
Crystal structure of drug resistant SRC kinase domain
Summary for 2QI8
Entry DOI | 10.2210/pdb2qi8/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, GLYCEROL (3 entities in total) |
Functional Keywords | src kinase domain; drug resistance, signaling protein, transferase |
Biological source | Gallus gallus (chicken) |
Cellular location | Cell membrane (By similarity): P00523 |
Total number of polymer chains | 2 |
Total formula weight | 65637.70 |
Authors | Michalczyk, A.,Rode, H.B.,Gruetter, C.,Rauh, D. (deposition date: 2007-07-03, release date: 2008-03-18, Last modification date: 2024-02-21) |
Primary citation | Michalczyk, A.,Kluter, S.,Rode, H.B.,Simard, J.R.,Grutter, C.,Rabiller, M.,Rauh, D. Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg.Med.Chem., 16:3482-3488, 2008 Cited by PubMed: 18316192DOI: 10.1016/j.bmc.2008.02.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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