2QI8
Crystal structure of drug resistant SRC kinase domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32772.8 | 2 | UniProt (P00523) Pfam (PF07714) | Gallus gallus (chicken) | p60-Src; c-Src; pp60c-src |
| 2 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | cloning artifact |
| His 249 | - | cloning artifact |
| Met 250 | - | cloning artifact |
| Met 338 | Thr 338 | engineered mutation |
| Cys 345 | Ser 345 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65545.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 65637.7 |
