3F3T
Kinase domain of cSrc in complex with inhibitor RL38 (Type III)
Summary for 3F3T
Entry DOI | 10.2210/pdb3f3t/pdb |
Related | 2QI8 2QLQ 2QQ7 3F3U 3F3V 3F3W |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea (3 entities in total) |
Functional Keywords | allosteric, type iii, dfg-out, alternative splicing, atp-binding, kinase, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase |
Biological source | Gallus gallus (Chicken) |
Cellular location | Cell membrane (By similarity): P00523 |
Total number of polymer chains | 2 |
Total formula weight | 66284.40 |
Authors | Gruetter, C.,Klueter, S.,Getlik, M.,Rauh, D. (deposition date: 2008-10-31, release date: 2009-03-03, Last modification date: 2023-11-01) |
Primary citation | Simard, J.R.,Kluter, S.,Grutter, C.,Getlik, M.,Rabiller, M.,Rode, H.B.,Rauh, D. A new screening assay for allosteric inhibitors of cSrc Nat.Chem.Biol., 5:394-396, 2009 Cited by PubMed: 19396179DOI: 10.1038/nchembio.162 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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