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3F3T

Kinase domain of cSrc in complex with inhibitor RL38 (Type III)

Summary for 3F3T
Entry DOI10.2210/pdb3f3t/pdb
Related2QI8 2QLQ 2QQ7 3F3U 3F3V 3F3W
DescriptorProto-oncogene tyrosine-protein kinase Src, 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea (3 entities in total)
Functional Keywordsallosteric, type iii, dfg-out, alternative splicing, atp-binding, kinase, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
Biological sourceGallus gallus (Chicken)
Cellular locationCell membrane (By similarity): P00523
Total number of polymer chains2
Total formula weight66284.40
Authors
Gruetter, C.,Klueter, S.,Getlik, M.,Rauh, D. (deposition date: 2008-10-31, release date: 2009-03-03, Last modification date: 2023-11-01)
Primary citationSimard, J.R.,Kluter, S.,Grutter, C.,Getlik, M.,Rabiller, M.,Rode, H.B.,Rauh, D.
A new screening assay for allosteric inhibitors of cSrc
Nat.Chem.Biol., 5:394-396, 2009
Cited by
PubMed: 19396179
DOI: 10.1038/nchembio.162
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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