5J5S
Src kinase in complex with a sulfonamide inhibitor
Summary for 5J5S
Entry DOI | 10.2210/pdb5j5s/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, N-{4-[8-amino-3-(propan-2-yl)imidazo[1,5-a]pyrazin-1-yl]naphthalen-1-yl}-N'-[3-(trifluoromethyl)phenyl]urea (3 entities in total) |
Functional Keywords | protein kinase, inactive kinase, sulfonamide inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Gallus gallus (Chicken) |
Cellular location | Cell membrane : P00523 |
Total number of polymer chains | 2 |
Total formula weight | 66462.30 |
Authors | Lebedev, I.,Feldman, H.C.,Georghiou, G.,Maly, D.J.,Seeliger, M. (deposition date: 2016-04-03, release date: 2016-06-01, Last modification date: 2023-09-27) |
Primary citation | Feldman, H.C.,Tong, M.,Wang, L.,Meza-Acevedo, R.,Gobillot, T.A.,Gliedt, M.J.,Hari, S.B.,Mitra, A.K.,Backes, B.J.,Papa, F.R.,Seeliger, M.A.,Maly, D.J. Structural and Functional Analysis of the Allosteric Modulation of IRE1a with ATP-Competitive Kinase Inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.153 Å) |
Structure validation
Download full validation report