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5J5S

Src kinase in complex with a sulfonamide inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BProto-oncogene tyrosine-protein kinase Srcpolymer28632726.62UniProt (P00523)
Pfam (PF07714)
In PDB
Gallus gallus (Chicken)Proto-oncogene c-Src,pp60c-src,p60-Src
2A, BN-{4-[8-amino-3-(propan-2-yl)imidazo[1,5-a]pyrazin-1-yl]naphthalen-1-yl}-N'-[3-(trifluoromethyl)phenyl]ureanon-polymer504.52Chemie (6G3)
3waterwater18.0295Chemie (HOH)
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
PDBExternal DatabaseDetails
Gly 248-expression tag
His 249-expression tag
Met 250-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight65453.3
Non-Polymers*Number of molecules2
Total formula weight1009.0
All*Total formula weight66462.3
*Water molecules are not included.

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PDB entries from 2024-07-10

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