3SOV
| The structure of a beta propeller domain in complex with peptide S | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Low-density lipoprotein receptor-related protein 6, ... | 著者 | Wang, W, Bourhis, E, Zhang, Y, Rouge, L, Wu, Y, Franke, Y, Cochran, A.G. | 登録日 | 2011-06-30 | 公開日 | 2011-09-21 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6. Structure, 19, 2011
|
|
7NAM
| LRP6_E1 in complex with Lr-EET-3.5 | 分子名称: | Low-density lipoprotein receptor-related protein 6, SODIUM ION, Trypsin inhibitor 2, ... | 著者 | Hansen, S, Hannoush, R.N. | 登録日 | 2021-06-21 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/ beta-catenin signaling. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
8FFE
| Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide | 分子名称: | GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ... | 著者 | Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C. | 登録日 | 2022-12-08 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-22 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
3SOB
| The structure of the first YWTD beta propeller domain of LRP6 in complex with a FAB | 分子名称: | CALCIUM ION, Low-density lipoprotein receptor-related protein 6, antibody heavy chain, ... | 著者 | Wang, W, Bourhis, E, Tam, C, Zhang, Y, Rouge, L, Wu, Y, Franke, Y, Cochran, A.G. | 登録日 | 2011-06-30 | 公開日 | 2011-09-21 | 最終更新日 | 2014-05-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6. Structure, 19, 2011
|
|
3SOQ
| The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Dickkopf-related protein 1, ... | 著者 | Wang, W, Bourhis, E, Zhang, Y, Rouge, L, Wu, Y, Franke, Y, Cochran, A.G. | 登録日 | 2011-06-30 | 公開日 | 2011-09-21 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6. Structure, 19, 2011
|
|
4A0P
| Crystal structure of LRP6P3E3P4E4 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Chen, S, Malinauskas, T, Aricescu, A.R, Siebold, C, Jones, E.Y. | 登録日 | 2011-09-11 | 公開日 | 2011-10-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and Functional Studies of Lrp6 Ectodomain Reveal a Platform for Wnt Signaling. Dev.Cell, 21, 2011
|
|
8DVM
| Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.6 | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Thakur, A.K, Liau, N.P.D, Sudhamsu, J, Hannoush, R.N. | 登録日 | 2022-07-29 | 公開日 | 2023-03-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering. Acs Chem.Biol., 18, 2023
|
|
4NM7
| Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 e-motif | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ADENOSINE-5'-DIPHOSPHATE, Axin-1, ... | 著者 | Stamos, J.L, Chu, M.L.-H, Enos, M.D, Shah, N, Weis, W.I. | 登録日 | 2013-11-14 | 公開日 | 2014-03-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife, 3, 2014
|
|
4NM5
| Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 c-motif | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Axin-1, CHLORIDE ION, ... | 著者 | Stamos, J.L, Chu, M.L.-H, Enos, M.D, Shah, N, Weis, W.I. | 登録日 | 2013-11-14 | 公開日 | 2014-03-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife, 3, 2014
|
|
8DVL
| Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.18 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Thakur, A.K, Liau, N.P.D, Sudhamsu, J, Hannoush, R.N. | 登録日 | 2022-07-29 | 公開日 | 2023-03-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering. Acs Chem.Biol., 18, 2023
|
|
8DVN
| Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.10 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Thakur, A.K, Liau, N.P.D, Sudhamsu, J, Hannoush, R.N. | 登録日 | 2022-07-29 | 公開日 | 2023-03-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering. Acs Chem.Biol., 18, 2023
|
|
5AIR
| |
6H15
| Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-B10 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Gros, P, van Scherpenzeel, R.C. | 登録日 | 2018-07-11 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells. Nat Commun, 10, 2019
|
|
3S2K
| Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ahn, V.E, Chu, M.L.-H, Choi, H.-J, Tran, D, Abo, A, Weis, W.I. | 登録日 | 2011-05-16 | 公開日 | 2011-11-02 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6. Dev.Cell, 21, 2011
|
|
3S94
| Crystal structure of LRP6-E1E2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Low-density lipoprotein receptor-related protein 6 | 著者 | Cheng, Z, Xu, W. | 登録日 | 2011-05-31 | 公開日 | 2011-11-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat.Struct.Mol.Biol., 18, 2011
|
|
3S8Z
| Crystal structure of LRP6-E3E4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Low-density lipoprotein receptor-related protein 6 | 著者 | Cheng, Z, Xu, W. | 登録日 | 2011-05-31 | 公開日 | 2011-10-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat.Struct.Mol.Biol., 18, 2011
|
|
4DG6
| Crystal structure of domains 1 and 2 of LRP6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Low-density lipoprotein receptor-related protein 6, PHOSPHATE ION | 著者 | Ceska, T.A, Doyle, C, Slocombe, P. | 登録日 | 2012-01-25 | 公開日 | 2012-06-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Characterization of the interaction of sclerostin with the LRP family of Wnt co-receptors To be Published
|
|
6H16
| |
3S8V
| Crystal structure of LRP6-Dkk1 complex | 分子名称: | Dickkopf-related protein 1, Low-density lipoprotein receptor-related protein 6 | 著者 | Cheng, Z, Xu, W. | 登録日 | 2011-05-31 | 公開日 | 2011-10-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat.Struct.Mol.Biol., 18, 2011
|
|
5FWW
| Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4) | 分子名称: | CALCIUM ION, DICKKOPF-RELATED PROTEIN 1, KREMEN PROTEIN 1, ... | 著者 | Zebisch, M, Jackson, V.A, Jones, E.Y. | 登録日 | 2016-02-21 | 公開日 | 2016-07-20 | 最終更新日 | 2016-09-28 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight Into Ternary Complex Formation with Lrp6 and Dickkopf Structure, 24, 2016
|
|
6L6R
| Crystal structure of LRP6 E1E2-SOST complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Choi, H.-J, Kim, J. | 登録日 | 2019-10-29 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains. Nat Commun, 11, 2020
|
|
8CTG
| Extracellular architecture of an engineered canonical Wnt signaling ternary complex | 分子名称: | Frizzled-8, Low-density lipoprotein receptor-related protein 6, PALMITOLEIC ACID, ... | 著者 | Tsutsumi, N, Jude, K.M, Garcia, K.C. | 登録日 | 2022-05-14 | 公開日 | 2023-03-15 | 最終更新日 | 2023-03-22 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8S7C
| Ternary Complex of Cachd1, FZD5 and LRP6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-5, ... | 著者 | Zhao, Y, Ren, J, Jones, E.Y. | 登録日 | 2024-02-29 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (4.7 Å) | 主引用文献 | Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science, 384, 2024
|
|
5GJE
| Three-dimensional reconstruction of human LRP6 ectodomain complexed with Dkk1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Matoba, K, Mihara, E, Tamura-Kawakami, K, Hirai, H, Thompson, S, Iwasaki, K, Takagi, J. | 登録日 | 2016-06-29 | 公開日 | 2017-01-18 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (21 Å) | 主引用文献 | Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1 Cell Rep, 18, 2017
|
|